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首页> 外文期刊>Journal of Allergy >Honeybee Venom Immunotherapy: A Comparative Study Using Purified and Nonpurified Aqueous Extracts in Patients with Normal Basal Serum Tryptase Concentrations
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Honeybee Venom Immunotherapy: A Comparative Study Using Purified and Nonpurified Aqueous Extracts in Patients with Normal Basal Serum Tryptase Concentrations

机译：蜜蜂毒液免疫治疗：基础血清类胰蛋白酶浓度正常的患者使用纯化和非纯化水提取物的比较研究

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摘要

In this study, we compared a purified aqueous extract and the corresponding nonpurified aqueous preparation under the same build-up protocol in bee venom allergic patients with a normal baseline mast cell tryptase concentration. Eighty patients with a history of a systemic reaction were enrolled for immunotherapy using a 5-day rush protocol. Patients treated with the purified extract and those treated with the non purified aqueous extract who developed a systemic reaction underwent maintenance therapy with the purified aluminium hydroxide adsorbed preparations. Patients treated with the nonpurified aqueous extract who did not experience a systemic reaction during the rush phase underwent the maintenance phase with that extract. Systemic reactions during the build-up phase occurred significantly more often in patients treated with nonpurified aqueous extract than in those treated with the corresponding purified aqueous preparations. During the one-year maintenance phase, no systemic reactions occurred in either of the groups. Neither age nor baseline mast cell tryptase concentration presented a significant correlation with the occurrence of a systemic reaction during the treatment, while the type of extract did. In conclusion, nonpurified aqueous extracts induced more frequent systemic reactions than the purified aqueous preparations, during the same rush protocol. The efficacy seemed to be comparable.
机译：在这项研究中，我们在基线肥大细胞类胰蛋白酶浓度正常的蜂毒过敏患者中，以相同的建立方案比较了纯化的水提取物和相应的非纯化的水制剂。使用5天急诊方案招募了80名有全身反应史的患者进行免疫治疗。用纯化的提取物治疗的患者和用未纯化的水提取物治疗的患者发生了全身性反应，接受了纯化的氢氧化铝吸附制剂的维持治疗。用未经纯化的水提取物治疗的患者在急躁期未经历全身性反应，因此接受了该提取物的维持阶段。与未使用相应的纯化水制剂治疗的患者相比，未纯化水提取物治疗的患者在累积阶段的全身反应发生的频率明显更高。在一年的维护阶段中，两组均未发生全身反应。年龄和肥大细胞类胰蛋白酶的基线浓度都与治疗期间全身反应的发生没有显着相关，而提取物的类型却没有。总之，在相同的仓促方案中，未纯化的水提物引起的全身反应比纯化的水剂更频繁。功效似乎是可比的。

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