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An Overlapping Syndrome of Allergy and Immune Deficiency in Children

机译：儿童过敏和免疫缺陷的重叠综合征

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Recurrent airway inflammations in children are an important clinical problem in pediatric practice. An essential challenge is differentiation between allergic background and immune deficiency, which is a difficult task taking into consideration individual predisposition to atopy, immune system maturation in the early childhood, as well as exposition to environmental allergens and microbial antigens. In this paper relationship between selected elements of innate and adaptive immunity, such as pattern-recognition receptors, complement components, dendritic cells, as well as immunoglobulins, and regulatory T lymph cells has been discussed. Particular attention has been paid to these mechanisms of the immune response which, depending on settings and timing of activation, predispose to allergy or contribute to tolerogenic phenotype. In the context of multifactorial conditioning of the innate and adaptive immunity governing the ultimate response and associations between allergy and immune deficiencies, these phenomena should be considered as pathogenetically not precluding, but as an overlapping syndrome.
机译：小儿反复呼吸道炎症是儿科实践中的重要临床问题。一个重要的挑战是过敏背景和免疫缺陷之间的区别，这是一项艰巨的任务，要考虑到个体易感性过敏症，儿童早期的免疫系统成熟以及暴露于环境过敏原和微生物抗原。在本文中，已讨论了固有免疫和适应性免疫的选定要素之间的关系，例如模式识别受体，补体成分，树突状细胞以及免疫球蛋白和调节性T淋巴细胞。已经特别注意了这些免疫应答的机制，这些机制取决于激活的设置和时间，容易引起过敏或促成致耐受性表型。在先天性和适应性免疫的多因素条件下，控制最终反应以及过敏和免疫缺陷之间的联系，这些现象应被认为不是致病性的，而不是排除性的，而是重叠的综合症。

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