Differential Effect of Unilateral Amygdalar GABAA Receptor Agonist Injection on Low- and High-Anxiety Rats

Maria P. Rysakova; Irina V. Pavlova

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Differential Effect of Unilateral Amygdalar GABAA Receptor Agonist Injection on Low- and High-Anxiety Rats

机译：单侧杏仁核GABAA受体激动剂注射液对低焦虑和高焦虑大鼠的差异作用

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The influence of γ-aminobutyric type-A (GABAA) receptors agonist (muscimol hydrobromide, 0.1 μg/0.5 μl) injections into the right or left basolateral amygdala (BLA) on the behavior of high-anxiety (HA) and low-anxiety (LA) rats subjected to the elevated plus-maze (EPM) test was investigated. Anxiolytic-like effects (increase of open-arm entries and open-arm time) was revealed only after administration of muscimol into the left (but not right) amygdala of HA animals. No effect was observed upon administration of muscimol to LA rats. These findings suggest an important role in anxiety regulation of the amygdalar GABA levels, and the assumed GABA hemispheric lateralization.

机译：右或左基底外侧杏仁核（BLA）注射γ-氨基丁酸A型（GABAA）受体激动剂（氢溴酸Muscimol，0.1μg/ 0.5μl）对高焦虑（HA）和低焦虑（研究了经受高迷宫（EPM）测试的LA）大鼠。只有在HA动物的左（但不是右）杏仁核中施用麝香酚后，才显示出抗焦虑样作用（张开双臂和张开双臂的时间增加）。向洛杉矶大鼠施用麝香酚后未观察到效果。这些发现表明在杏仁核GABA水平的焦虑调节和假定的GABA半球侧偏中起重要作用。

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《Journal of Behavioral and Brain Science》 |2016年第1期|共10页
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Maria P. Rysakova; Irina V. Pavlova;
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中图分类神经病学与精神病学;
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Differential Effect of Unilateral Amygdalar GABAA Receptor Agonist Injection on Low- and High-Anxiety Rats

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