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首页> 外文期刊>Journal of atherosclerosis and thrombosis. >Different Impacts of Cardiovascular Risk Factors on Arterial Stiffness versus Arterial Wall Thickness in Japanese Patients with Type 2 Diabetes Mellitus
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Different Impacts of Cardiovascular Risk Factors on Arterial Stiffness versus Arterial Wall Thickness in Japanese Patients with Type 2 Diabetes Mellitus

机译：日本2型糖尿病患者的心血管危险因素对动脉僵硬度和动脉壁厚度的不同影响

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Aim : We statistically investigated whether the impact of cardiovascular risk factors on arterial stiffness would be different from that on arterial wall thickness. Methods : We analyzed 1648 Japanese type 2 diabetic patients. Arterial stiffness was evaluated by pulse wave verbosity (PWV) and wall thickness was assessed with carotid intima-media thickness (IMT) by ultrasonography. We developed a common regression model to PWV and IMT by extending the linear mixed model and statistically detected the difference in the impact of cardiovascular risk factors between the two indices. Results : There was a significant correlation between PWV and IMT ( r =0.365, p ＜0.001). Sex, diabetic duration, hemoglobin A1c levels, and the presence of retinopathy and cardiovascular disease were comparable independent risk factors for elevated PWV and IMT. On the other hand, the impact of age, systolic blood pressure, and low- and high-density lipoprotein cholesterol levels were significantly different between the two measurements (all p ＜0.05). Cholesterol levels were significantly associated with IMT but not with PWV. Age and systolic blood pressure had a significant impact on both measurements, but the impact on PWV was significantly greater than that on IMT. Indeed, patients with low IMT but with advanced age and high systolic pressure had high PWV, whereas patients with low PWV but with impaired cholesterol levels had high IMT. Conclusion : The extended linear mixed model statistically confirmed that the impact of cardiovascular risk factors on elevated PWV and IMT were not identical in Japanese patients with type 2 diabetes mellitus.
机译：目的：我们统计地调查了心血管危险因素对动脉僵硬度的影响是否与对动脉壁厚度的影响不同。方法：我们分析了1648例日本2型糖尿病患者。通过脉搏波详细程度（PWV）评估动脉僵硬度，并通过超声检查以颈动脉内膜中层厚度（IMT）评估壁厚。通过扩展线性混合模型，我们开发了PWV和IMT的通用回归模型，并统计地检测了两个指标之间心血管危险因素的影响差异。结果：PWV与IMT之间存在显着相关性（r = 0.365，p ＜0.001）。性别，糖尿病病程，血红蛋白A1c水平以及视网膜病变和心血管疾病的存在是可比较的PWV和IMT升高的独立危险因素。另一方面，两次测量之间的年龄，收缩压，低密度脂蛋白胆固醇和高密度脂蛋白胆固醇水平的影响均存在显着差异（均p ＜0.05）。胆固醇水平与IMT显着相关，而与PWV无关。年龄和收缩压对两种测量都有显着影响，但对PWV的影响明显大于对IMT的影响。确实，IMT低但年龄较大且收缩压高的患者PWV高，而PWV低但胆固醇水平受损的患者IMT高。结论：扩展线性混合模型在统计学上证实了日本2型糖尿病患者心血管危险因素对PWV和IMT升高的影响并不相同。

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