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首页> 外文期刊>Journal of Behavioral and Brain Science >Behavioral and Neurobiological Assessments of Predator-Based Fear Conditioning and Extinction
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Behavioral and Neurobiological Assessments of Predator-Based Fear Conditioning and Extinction

机译：基于捕食者的恐惧调节和消灭的行为和神经生物学评估

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Shock, immobilization, and exposure to predator-related stimuli have all been used to study fear conditioning in rodents, but they have never been used in conjunction in a single study. Experiment 1 compared the effects of these three reinforcers, alone and in various combinations, on the expression of long-term conditioned fear memory and extinction in adult male rats. Whereas foot shock conditioning, alone, was rapidly extinguished; the combination of immobilization and cat exposure, or all 3 stimuli together, produced a significant increase in the magnitude of fear conditioning and greater resistance to extinction, which persisted for at least 5 weeks post-training (p < 0.05). Experiment 2 assessed the role of the hippocampus in predator-based context and cued fear conditioning. Pharmacological suppression of hippocampal activity during fear conditioning produced a selective impairment of contextual, but not cued, fear memory. Experiment 3 investigated the effects of sleep deprivation prior to fear conditioning on the expression of fear memory. This experiment demonstrated that pre-training sleep deprivation blocked the expression of contextual (hippocampal-dependent), but not cued (hippocampal-independent), fear memory. Overall, this series of experiments has extended the use of predator exposure in conjunction with conventional reinforcers, such as foot shock and immobilization, to advance our understanding of the neurobiology of traumatic memory.
机译：休克，固定和暴露于与捕食者相关的刺激都已用于研究啮齿动物的恐惧状况，但从未将它们用于单个研究中。实验1比较了这三种增强剂在成年雄性大鼠中单独和各种组合对长期条件性恐惧记忆和绝灭表达的影响。单独的足部震动调节很快消失了;固定和猫的接触或全部3种刺激的结合，使恐惧调节的程度显着增加，并且对灭绝的抵抗力增强，在训练后至少持续了5周（p <0.05）。实验2评估了海马在以捕食者为基础的环境中的作用并提示恐惧条件。在恐惧调节过程中，海马活性的药理学抑制作用产生了对上下文的恐惧记忆的选择性损害，但没有提示。实验3研究了在恐惧调节之前剥夺睡眠对恐惧记忆表达的影响。该实验表明，训练前的睡眠剥夺阻止了上下文（海马依赖）表达，但没有提示（海马独立）提示恐惧记忆的表达。总的来说，这一系列实验扩大了捕食者暴露与常规增强剂（如脚震和固定）的结合使用，以增进我们对创伤记忆神经生物学的理解。

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