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首页> 外文期刊>Journal of Behavioral and Brain Science >Transthyretin—A Key Gene Involved in Regulating Learning and Memory in Brain, and Providing Neuroprotection in Alzheimer Disease via Neuronal Synthesis of Transthyretin Protein
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Transthyretin—A Key Gene Involved in Regulating Learning and Memory in Brain, and Providing Neuroprotection in Alzheimer Disease via Neuronal Synthesis of Transthyretin Protein

机译：运甲状腺素蛋白—涉及调节大脑学习和记忆并通过运甲状腺素蛋白蛋白的神经元合成为阿尔茨海默病提供神经保护的关键基因

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Transthyretin (TTR), a carrier protein present in the liver and choroid plexus of the brain, has been shown to be responsible for binding thyroid hormone thyroxin (T4) and retinol in plasma and cerebrospinal fluid (CSF). TTR aids in sequestering of beta-amyloid peptides Aβ deposition, and protects the brain from trauma, ischemic stroke and Alzheimer disease (AD). Accordingly, hippocampal gene expression of TTR plays a significant role in learning and memory as well as in simulation of spatial memory tasks. TTR via interacting with transcription factor CREB regulates this process and decreased expression leads to memory deficits. By different signaling pathways, like MAPK, AKT, and ERK via Src, TTR provides tropical support through megalin receptor by promoting neurite outgrowth and protecting the neurons from traumatic brain injury. TTR is also responsible for the transient rise in intracellular Ca2+ via NMDA receptor, playing a dominant role under excitotoxic conditions. In this review, we tried to shed light on how TTR is involved in maintaining normal cognitive processes, its role in learning and memory, under memory deficit conditions; by which mechanisms it promotes neurite outgrowth; and how it protects the brain from Alzheimer disease (AD).
机译：运甲状腺素蛋白（TTR）是存在于大脑的肝脏和脉络丛中的一种载体蛋白，已被证明与血浆和脑脊液（CSF）中的甲状腺激素甲状腺素（T4）和视黄醇结合。 TTR有助于隔离β-淀粉样肽A β沉积，并保护大脑免受创伤，缺血性中风和阿尔茨海默氏病（AD）的侵害。因此，TTR的海马基因表达在学习和记忆以及空间记忆任务的模拟中起重要作用。 TTR通过与转录因子CREB相互作用来调节此过程，并且表达降低会导致记忆缺陷。通过不同的信号通路，例如通过Src的MAPK，AKT和ERK，TTR通过促进神经突向外生长并保护神经元免受颅脑损伤，通过巨蛋白受体提供热带支持。 TTR还负责通过NMDA受体使细胞内Ca 2 + 瞬时升高，在兴奋性毒性条件下起主导作用。在这篇综述中，我们试图阐明在记忆力不足的情况下，TTR如何参与维持正常的认知过程，其在学习和记忆中的作用。它通过哪种机制促进神经突向外生长;以及它如何保护大脑免受老年痴呆症（AD）的侵害。

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