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首页> 外文期刊>Journal of Applied Life Sciences International >Chemical Elemental Content/Calcium Ratios in Tissues of Human Hyperplastic Prostate Gland
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Chemical Elemental Content/Calcium Ratios in Tissues of Human Hyperplastic Prostate Gland

机译:人增生前列腺组织中的化学元素含量/钙比

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Aims: The aim of this exploratory study was to evaluate whether significant deficiencies in the prostatic tissue levels of Ca and Mg, as androgen dependent chemical elements, and Br, K, Mn, and Na, as androgen independent chemical elements, exist in patients with BPH. Methodology: It was prospectively evaluated prostatic tissue levels of these chemical elements in 27 patients with BPH and 37 healthy male inhabitants. Measurements were performed using instrumental neutron activation analysis with high resolution spectrometry of short-lived radionuclides. Beside the measurements of Br, Ca, K, Mg, Mn, and Na mass fraction the calculations of Br/Ca, K/Ca, Mg/Ca, Mn/Ca, and Na/Ca mass fraction ratios were also performed. Results: There was no found significant difference in levels of Br, Ca, Mg, Mn, and Na contents between BPH and intact prostate. In the hyperplastic prostates, we have only observed a significant increase in value of K mass fraction ( p <0.0014) and K/Ca mass fraction ratio ( p <0.042). Conclusion: The potential role of age-related chemical elements deficiency in the prostate was not confirmed as being involved in the etiology of BPH. It was hypothesized that not only a high level of some chemical elements, but also a great disturbance in the relationships of chemical elements in prostate tissue may serve as a pathogenetic factor of BPH.
机译:目的:这项探索性研究的目的是评估前列腺癌患者中前列腺组织中钙和镁的水平是否存在显着缺陷(作为雄激素依赖性的化学元素)以及溴,钾,锰和钠作为雄激素依赖性的化学元素。 BPH。方法:前瞻性评估了27名BPH患者和37名健康男性居民中这些化学元素的前列腺组织水平。使用仪器中子活化分析和短寿命放射性核素的高分辨率光谱进行测量。除了测量Br,Ca,K,Mg,Mn和Na质量分数外,还执行Br / Ca,K / Ca,Mg / Ca,Mn / Ca和Na / Ca质量分数比的计算。结果:BPH和完整前列腺之间的Br,Ca,Mg,Mn和Na含量水平没有显着差异。在增生性前列腺中,我们仅观察到K质量分数(p <0.0014)和K / Ca质量分数之比(p <0.042)的显着增加。结论:年龄相关化学元素缺乏在前列腺中的潜在作用尚未被证实是BPH的病因。假设不仅某些化学元素含量高,而且前列腺组织中化学元素之间的关系受到极大干扰也可能是BPH的致病因素。

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