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首页> 外文期刊>Journal of Armed Forces Medical College, Bangladesh >Seroprevalence of Rubella Antibodies in Pregnant Women
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Seroprevalence of Rubella Antibodies in Pregnant Women

机译：孕妇风疹抗体的血清阳性率

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Introduction: Clinical or subclinical infection of rubella of pregnant mother gives rise to a handicap baby to the society. Some time affected baby born apparently normal, but subsequently expresses disability. Objective: This study was carried out to see the seroprevalence of rubella antibodies in pregnant women. Method: Single blood sample was taken from 134 pregnant women, 66 from 1st trimester, 36 from 2nd trimester and 32 from 3rd trimester. Blood samples were collected from different Out Patient Departments (OPD) of Combined Military Hospital (CMH) and Armed Forces Institute of Pathology (AFIP) over a period of six months. All the sera were examined by enzyme-linked immunosorbant assay (ELISA) for rubella specific Immunoglobulin M (IgM) and Immunoglobulin G (IgG). Result: The over all prevalence of seropositivity for IgG was 84.33% indicating that they were immune for rubella infection and the rest 15.67% were susceptible for rubella infection. The seropositivity for IgM antibody was 0.75%, which was a single case found in 22 year old pregnant women in 3rd trimester and was 2nd gravida. The study demonstrated that 85.71% of the pregnant women between the ages of 15 to 20 years had rubella IgG, peaking at 87.80% in the age group 26-30 years and the seropositivity lower to 66.67% in the age group 31- 35 years. Analysis of rubella specific IgG antibody among the different socio-economic group population in the present study, showed that seropositivity rate was much higher in lower (91.67%) socio-economic status group, 89.02% in middle status group and the difference was lower in upper (72.50%) socioeconomic status group and the difference was statistically significant (p<0.05). Higher (86.84%) incidence of seropositivity for IgG antibody was observed in women presenting with adverse pregnancy out comes than that the normal pregnancy (80.65%) out comes group. Conclusion: The present study revealed that the substantial percentage of pregnant women were susceptible for rubella infection. The findings of this study will help to formulate a guideline for taking nation wide vaccination program.
机译：简介：孕妇母亲风疹的临床或亚临床感染为社会带来了残疾婴儿。有一段时间，受影响的婴儿显然正常，但随后表现出残疾。目的：本研究旨在观察孕妇风疹抗体的血清阳性率。方法：从134名孕妇中抽取单血样本，从妊娠前三个月抽取66例，从妊娠中期三个月抽取36例，妊娠中期三个月抽取32例。在六个月的时间里，从联合军事医院（CMH）和武装部队病理研究所（AFIP）的不同门诊部（OPD）采集了血液样本。通过酶联免疫吸附法（ELISA）检查所有血清的风疹特异性免疫球蛋白M（IgM）和免疫球蛋白G（IgG）。结果：IgG血清阳性的总体患病率为84.33％，表明它们对风疹感染具有免疫力，其余的15.67％对风疹感染易感。 IgM抗体的血清阳性率为0.75％，这是在妊娠晚期的22岁孕妇中发现的一例，是第二胎。研究表明，年龄在15至20岁之间的孕妇中有85.71％患有风疹IgG，在26-30岁的年龄组中最高达到87.80％，血清阳性在31-35岁的年龄组中降至66.67％。本研究对不同社会经济群体的风疹特异性IgG抗体进行分析，结果表明，社会经济地位较低的人群（91.67％）的血清阳性率高得多，中层社会地位人群的血清阳性率高（89.02％），而低社会地位人群的血清阳性率低。较高（72.50％）的社会经济地位组，差异具有统计学意义（p <0.05）。出现不良妊娠的妇女中，IgG抗体血清阳性的发生率高于正常妊娠组的妇女（80.65％）。结论：本研究表明，相当大比例的孕妇易感染风疹。这项研究的结果将有助于制定全国疫苗接种计划的指导方针。

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