...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Armed Forces Medical College, Bangladesh >Variations of Lung Function Status in Hypertension and Antihypertensive Medication
【24h】

Variations of Lung Function Status in Hypertension and Antihypertensive Medication

机译：高血压和降压药物治疗中肺功能状态的变化

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: Essential hypertension is associated with altered pulmonary function. Antihypertensive medication and lung function are also associated. Amlodipine (calcium channel blocker) and Atenolol (beta blocker) are commonly used antihypertensive drugs. Objective: To evaluate the effects of antihypertensive drugs on lung function status in patients with essential hypertension. Materials and Methods: This prospective observational study was carried out in the Department of Physiology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka, from July 2012 to June 2013 on 100 newly diagnosed essential hypertensive patients. Based on prescribed treatment, these study subjects were divided into two groups - B1 and B2. B1 included 50 patients who received amlodipine 5mg daily and B2 included 50 patients who received atenolol 50mg daily. Lung function tests were done in both B1 and B2 groups before taking medication, after 3 months of medication and after 6 months of medication. For assessing lung function status, Forced Vital Capacity (FVC), Forced Expiratory Volume in 1st second (FEV1) and Peak Expiratory Flow Rate (PEFR) were measured with a computer based Spirometer. Age, sex and BMI matched 50 apparently healthy normotensive subjects were also studied as control (group A). Data were compared among subjects of different groups. For statistical analysis independent sample‘t’ test and paired sample‘t’ test were performed. Results: Mean FVC, FEV1 and PEFR were significantly lower in newly diagnosed hypertensive patients in comparison with that of healthy normotensive subjects. Mean FVC, FEV1 and PEFR were found significantly higher in the group taking amlodipine for 6 months when compared to newly diagnosed hypertensive patients but lower than those of controls. In addition mean FVC and FEV1 were found significantly lower in the group taking atenolol for 6 months when compared to newly diagnosed hypertensive patients and those of controls. Conclusion: Reduced lung function occurs in newly diagnosed essential hypertensive patients which improve by treatment with amlodipine but decreases after treatment with atenolol.
机译：简介：原发性高血压与肺功能改变有关。降压药物和肺功能也相关。氨氯地平（钙通道阻滞剂）和阿替洛尔（β阻滞剂）是常用的降压药。目的：评价降压药对原发性高血压患者肺功能状态的影响。材料和方法：这项前瞻性观察研究于2012年7月至2013年6月在达卡沙哈巴格的Bangabandhu Sheikh Mujib医科大学生理学系（BSMMU）上对100名新诊断的原发性高血压患者进行了研究。根据规定的治疗方法，将这些研究对象分为两组-B1和B2。 B1包括50例每天接受5mg氨氯地平的患者，B2包括50例每天接受50mg阿替洛尔的患者。在服药前，服药3个月后和服药6个月后，对B1和B2组均进行了肺功能测试。为了评估肺功能状态，使用基于计算机的肺活量计测量了强迫肺活量（FVC），第一秒强迫呼气量（FEV1）和呼气峰值流速（PEFR）。年龄，性别和BMI相匹配的50名显然健康的血压正常受试者也被作为对照组（A组）。比较不同组受试者之间的数据。为了进行统计分析，执行了独立样本“ t”检验和配对样本“ t”检验。结果：与健康的正常血压受试者相比，新诊断的高血压患者的平均FVC，FEV1和PEFR显着降低。与新诊断的高血压患者相比，服用氨氯地平6个月的组的平均FVC，FEV1和PEFR显着较高，但低于对照组。此外，与新诊断的高血压患者和对照组相比，服用阿替洛尔6个月的组的平均FVC和FEV1显着降低。结论：新诊断的原发性高血压患者出现肺功能下降，氨氯地平治疗可改善肺功能，但阿替洛尔治疗后可降低。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号