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首页> 外文期刊>Journal of Armed Forces Medical College, Bangladesh >Evaluation of Sympathetic Nerve Function Status in Hypertensive Patients
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Evaluation of Sympathetic Nerve Function Status in Hypertensive Patients

机译：高血压患者交感神经功能状态评估

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Introduction: Hypertension is independent and the most powerful predictor of cardiovascular morbidity and mortality. Sympathetic overdrive may be related to essential hypertension. Heart Rate Variability (HRV) analysis is one of the most quantitative markers of autonomic activity in hypertensive patients. Objective: To assess the cardiac autonomic nerve function status by heart rate variability in essential hypertension. Materials and Methods: This cross sectional study was carried out to observe the HRV in 60 hypertensive male patients with age ranging from 40-60 years (group B) in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU) from 1st July 2008 to 30th June 2009. Based on treatment, hypertensive patients were divided into B1 (untreated patients on their 1st day of diagnosis) and B2 (patients with antihypertensive therapy for less than 5 years). For comparison, 30 apparently healthy normotensive subjects (group A) matched by age sex were also studied. The study group was selected from the Out Patient Department of Cardiology, BSMMU, Dhaka and the control group was selected by personal contact. Heart Rate Variability parameters were assessed by Polygraph (RMS Polyrite D, version2.2) and for statistical analysis Independent sample t-test, One-way ANOVA test, Chi-square test and Pearson’s correlation coefficient tests were done as applicable. Results: LF/HF(Low Frequency/High Frequency) ratio and LF norm (normalized unit) were significantly (p0.001) higher and HF norm was significantly (p0.001) lower in untreated hypertensive patients in comparison to those of healthy normotensive subjects. parameters were observed between treated hypertensive and healthy control subjects. The LF/HF ratio and LF norm showed positive correlations and HF norm showed negative correlations with SBP (systolic blood pressure) and DBP (diastolic blood pressure) in both the hypertensive groups. However, all these findings were more marked in untreated hypertensive patients than those of treated group. Conclusion: Hypertensive patients may have sympathovagal imbalance and is usually characterized by higher sympathetic as well as lower vagal modulation of the heart rate.
机译：简介：高血压是独立的，是心血管疾病发病率和死亡率的最有力预测指标。交感神经超速可能与原发性高血压有关。心率变异性（HRV）分析是高血压患者自主神经活动最定量的指标之一。目的：通过心率变异性评估原发性高血压的心脏自主神经功能状态。材料和方法：这项横断面研究从2008年7月1日开始在Bangabandhu Sheikh Mujib医科大学生理学系（BSMMU）的60名年龄在40-60岁的高血压男性患者（B组）中进行观察。至2009年6月30日。根据治疗方法，高血压患者分为B1（诊断第一天未接受治疗的患者）和B2（接受降压治疗少于5年的患者）。为了进行比较，还研究了30名年龄匹配的，看起来健康的血压正常的受试者（A组）。研究组选自达卡BSMMU的门诊心脏病科，而对照组则是通过个人接触选择的。心率变异性参数通过Polygraph（RMS Polyrite D，版本2.2）进行评估，并进行统计分析，并进行了独立样本t检验，单向ANOVA检验，卡方检验和Pearson相关系数检验。结果：与正常血压正常者相比，未经治疗的高血压患者的LF / HF（低频/高频）比率和LF规范（标准化单位）显着较高（p <0.001），HF规范显着（p <0.001）降低科目。在治疗的高血压和健康对照受试者之间观察到参数。在两个高血压组中，LF / HF比和LF规范与SBP（收缩压）和DBP（舒张压）呈正相关，HF规范与负压相关。但是，所有这些发现在未经治疗的高血压患者中比在治疗组中更为明显。结论：高血压患者可能存在交感神经迷失平衡，通常以较高的交感神经和迷走神经对心率的调节为特征。

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