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首页> 外文期刊>Journal of Armed Forces Medical College, Bangladesh >A Comparative Study on Efficacy of 30% Trichloroacetic Acid versus 35% Glycolic Acid Peel in the Treatment of Melasma
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A Comparative Study on Efficacy of 30% Trichloroacetic Acid versus 35% Glycolic Acid Peel in the Treatment of Melasma

机译：30％三氯乙酸与35％乙醇酸果皮治疗黄褐斑疗效比较研究

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Introduction: Melasma is a common hyperpigmented disorder of skin which has severe impact on the quality of life. Many modalities of treatment are available to treat melasma. Among them chemical peeling is one of the most popular and widely used method of treatment for melasma. Objective: The present study was aimed to assess the efficacy of 30% trichloroacetic acid versus 35% glycolic acid peel in the treatment of melasma. Materials and Methods: The prospective randomized study included 50 patients of melasma of both sexes, in 20-55 years age group. Patients were randomly divided into two equal groups A and B. Group A was treated with trichloroacetic acid (TCA 30%) peel and group B with glycolic acid (GA 35%) peel. Five peels were done serially at intervals of 21 days. Patients were followed up every 3 weekly for 6 weeks after the last peel. The disease severity was monitored with digital photography and melasma area and severity index (MASI) score which were calculated at baseline, 6 weeks, 12 weeks and 18 weeks. A visual analog scale (VAS) was calculated at baseline, 12 weeks and 18 weeks. Results: Glycolic acid showed better response compared to trichloroacetic acid at the end of five peels, but this difference was not statistically significant (p0.05). Chemical peeling with trichloroacetic acid produced significantly more erythema, burning sensation (p0.05) and higher incidence of post peel inflammatory hyperpigmentation (p 0.05) compared to glycolic acid.
机译：简介：黄褐斑是一种常见的色素沉着过度的皮肤疾病，对生活质量产生严重影响。治疗黄褐斑的方法很多。其中化学脱皮是最流行和广泛使用的黄褐斑治疗方法之一。目的：本研究旨在评估30％三氯乙酸与35％乙醇酸果皮治疗黄褐斑的疗效。资料和方法：前瞻性随机研究包括20-55岁年龄段的50名男女黄褐斑患者。将患者随机分为两组，分别为A组和B组。A组用三氯乙酸（TCA 30％）皮治疗，B组用乙醇酸（GA 35％）皮治疗。每隔21天连续进行5次剥皮。最后一次剥离后，每3周对患者进行一次随访，持续6周。用数字摄影以及黄褐斑面积和严重程度指数（MASI）评分监测疾病的严重程度，这些评分是在基线，6周，12周和18周时计算得出的。在基线，12周和18周时计算视觉模拟量表（VAS）。结果：乙醇酸在三层果皮末显示出比三氯乙酸更好的响应，但该差异无统计学意义（p> 0.05）。与乙醇酸相比，用三氯乙酸进行化学脱皮会产生更多的红斑，灼热感（p <0.05），并且脱皮后炎症性色素沉着的发生率更高（p <0.05）。

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