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首页> 外文期刊>Journal of Behavioral and Brain Science >Cocaine Alters the Daily Activity Patterns of Adult SD Female Rats
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Cocaine Alters the Daily Activity Patterns of Adult SD Female Rats

机译：可卡因改变成年SD雌性大鼠的日常活动模式

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The effects of chronic cocaine administration on the locomotor rhythmic patterns of adult female Sprague-Dawley (SD) rats were recorded using an open-field testing assay. The animals were divided into four groups, control (saline), 3.0 mg/kg, 7.5 mg/kg, and 15.0 mg/kg i.p. cocaine group respectively. On experimental day (ED 1), all animals were treated with saline. On ED 2 to ED 7, either saline or cocaine (3.0, 7.5, or 15.0 mg/kg i.p.) was given followed by three days of no treatment (ED 8 to ED 10). On ED 11, rats were treated as they were on ED 2 to ED 7, i.e. either saline, 3.0, 7.5, or 15.0 mg/kg i.p. cocaine. The locomotor activities of rats were recorded for 23 hours daily, allowing one hour for the animal handling and injections, using open field cages with 16 infrared beams of motion detectors. Any breakages of these beams due to the movement of the animals were recorded and compiled by a computer and analyzed. It was observed that all three doses of repeated cocaine administration (3.0 mg/kg, 7.5 mg/kg, and 15.0 mg/kg i.p. cocaine) significantly alter the locomotor rhythmic activity patterns of the adult female SD rats, which suggest that repeated cocaine exposure modulates body homeostasis.
机译：使用开放视野测试法记录了长期服用可卡因对成年雌性Sprague-Dawley（SD）大鼠运动节律的影响。将动物分成四组，即对照组（盐水），3.0mg / kg，7.5mg / kg和15.0mg / kg的腹腔注射。可卡因组。在实验日（ED 1），所有动物均用盐水处理。在ED 2至ED 7上，给予生理盐水或可卡因（3.0、7.5或15.0 mg / kg腹腔注射），然后三天不进行治疗（ED 8至ED 10）。在ED 11上，按ED 2至ED 7的方式对大鼠进行治疗，即盐水，3.0、7.5或15.0 mg / kg i.p.。可卡因。每天记录大鼠的运动能力23小时，使用带有16个红外光束的运动检测器的开放式笼子对动物进行一小时的处理和注射。这些光束由于动物的运动而造成的任何破损均由计算机记录和编辑，然后进行分析。观察到，所有三剂重复可卡因给药（3.0 mg / kg，7.5 mg / kg和15.0 mg / kg ip可卡因）均会显着改变成年雌性SD大鼠的运动节律活动模式，这表明反复接触可卡因调节身体稳态。

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