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首页> 外文期刊>Journal of Applied Life Sciences International >Effect of Route of Administration on Immune Response of Broiler Chicks to Newcastle Disease Vaccine (LaSota)
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Effect of Route of Administration on Immune Response of Broiler Chicks to Newcastle Disease Vaccine (LaSota)

机译：施用途径对肉鸡对新城疫疫苗（LaSota）免疫反应的影响

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Aims: This work was undertaken to study the immune response of broiler chicks to LaSota vaccine by using different routes of administration. Study Design: The design used was a completely randomized design. Place and Duration of Study: The study was carried out at the Poultry Unit of the Kogi State University Teaching and Research Farm Anyigba, Kogi State, Nigeria. It lasted for 5 weeks. Methodology: One hundred day old broiler chicks were grouped into 4 of 25 chicks each (A, B, C and D). In the 3rd week of life, the groups were vaccinated with LaSota by intraocular (i/o), intramuscular (i/m) and oral (per os) routes respectively while Group D served as the unvaccinated control group. Five chicks from each group were randomly selected and bled at 2, 3, 4 and 5 weeks post LaSota vaccination. Their sera were used for Haemagglutination Inhibition (HI) test. Results: All the routes used produced high levels of Haemagglutination Inhibition (HI) antibody titres two weeks post vaccination. Immunity fell below protective level after 5 weeks post vaccination Conclusion: All the routes in this study were immunogenic and vaccination failure may not necessarily be due to the route of administration of vaccine.
机译：目的：通过不同的给药途径，研究肉鸡对LaSota疫苗的免疫反应。研究设计：使用的设计是完全随机的设计。研究的地点和持续时间：该研究是在尼日利亚科吉州科吉州立大学教学与研究农场Anyigba的家禽部门进行的。它持续了5个星期。方法：将一百日龄的肉仔鸡分为25只，每只4只（A，B，C和D）。在生命的第3周中，各组分别通过眼内（i / o），肌内（i / m）和口服（每os）途径接种LaSota疫苗，而D组为未接种疫苗控制组。 LaSota疫苗接种后第2、3、4和5周，随机选择每组五只小鸡并放血。他们的血清用于血凝抑制（HI）测试。结果：接种后两周，所有使用的途径均产生高水平的血凝抑制（HI）抗体滴度。接种疫苗5周后，免疫力降至保护水平以下结论：本研究中的所有途径均为免疫原性，接种失败可能不一定是疫苗接种途径所致。

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