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首页> 外文期刊>Journal of Applied Life Sciences International >Ameliorative Effect of Gongronema latifolium Leaf Diets on Hematological and Immunological Disturbances in Streptozotozin-induced Diabetic Rats
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Ameliorative Effect of Gongronema latifolium Leaf Diets on Hematological and Immunological Disturbances in Streptozotozin-induced Diabetic Rats

机译：弓形虫叶片日粮对链脲佐菌素诱导的糖尿病大鼠血液和免疫功能的改善作用

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Aim: The aim of this study was to determine some biomarkers of immunology and hematology in streptozotocin- induced diabetic wistar rats consuming Gongronema latifolium leaf diets in order to evaluate the involvement of the diet in the management of immunological and hematological complications common among diabetics. Study Design: The design consisted of fifty rats randomly divided into five groups (1, 2, 3, 4 and 5) of 10 rats per group. Group 1(normal control) was fed with control diet; Group 2 (diabetic control) was fed with control diet; Group 3 and 4 (diabetic, diet treated) were fed with Gongronema latifolium at 5% and 7.5% respectively. Group 5 (diabetic, insulin treated) was fed with control diet and treated with insulin. Feed and water were given ad- libitum for 28 days. Place and Duration of Research: The Research took place at the Department of Biochemistry, University of Calabar, Nigeria between March, 2011 and May, 2012. Methodology: Biomarkers of hematology and immunology were determined using standard methods. Results: Results showed that diabetic rats in groups 3 and 4 consuming Gongronema latifolium diet had significant increase ( P = .02) in the RBC, hemoglobin, and lymphocyte counts relative to the diabetic control. Diabetic rats consuming Gongronema latifolium had significant reduction ( P = .02) in the level of WBC, platelets, neutrophil, and CD4+ cell count relative to the diabetic control. The results for diabetic rats in groups 3 and 4 consuming Gongronema latifolium diets were similar to those on Insulin (group 5) for the measured parameters and were not significantly different when compared to the normal control rats ( group 2). Conclusion: We concluded that consumption of diets containing Gongronema latifolium leaves has positive effect on the immunological and hematological abnormalities associated with diabetes mellitus and might constitute a diet- based treatment or adjunct for treatment of immunological and hematological disturbances common among diabetics.
机译：目的：本研究的目的是确定食用链格线菌叶饮食的链脲佐菌素诱导的糖尿病wistar大鼠的免疫学和血液学的一些生物标志物，以评估饮食对糖尿病患者常见的免疫学和血液学并发症的管理。研究设计：设计包括五十只大鼠，随机分为五组（1、2、3、4和5），每组10只。第1组（正常对照组）喂养对照饮食;第2组（糖尿病对照）喂养对照饮食;第3组和第4组（糖尿病，饮食治疗）分别以5％和7.5％的剂量饲喂弓形虫。给第5组（糖尿病，胰岛素治疗）喂食对照饮食并用胰岛素治疗。随意喂食和饮水28天。研究的地点和持续时间：该研究于2011年3月至2012年5月在尼日利亚卡拉巴尔大学生物化学系进行。方法：血液学和免疫学的生物标志物采用标准方法进行测定。结果：结果显示，食用Gongronema latifolium饮食的第3组和第4组的糖尿病大鼠相对于糖尿病对照组，其RBC，血红蛋白和淋巴细胞计数显着增加（P = .02）。与糖尿病对照组相比，食用弓形虫的糖尿病大鼠的WBC，血小板，嗜中性白细胞和CD 4 + 细胞数量显着降低（P = .02）。食用Gongronema latifolium饮食的第3组和第4组的糖尿病大鼠的测量参数与胰岛素（第5组）的相似，与正常对照组（第2组）相比无显着差异。结论：我们得出结论，食用含弓形虫叶的饮食对糖尿病相关的免疫学和血液学异常具有积极作用，并且可能构成以饮食为基础的治疗方法或辅助治疗糖尿病患者常见的免疫学和血液学疾病。

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