...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Applied Life Sciences International >In vivo Evaluation of Antidiabetic Properties of Seed Oil of Moringa oleifera Lam
【24h】

In vivo Evaluation of Antidiabetic Properties of Seed Oil of Moringa oleifera Lam

机译：辣木籽油抗糖尿病特性的体内评价

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aim: To investigate the antidiabetic properties of seed oil of Moringa oleifera Lam. Extracted with petroleum ether and dichloromethane and compared with glibenclimide. Study Design: Experimental study design was adopted. Methodology: The 2.0 ml/kg body weight (kg.bw) of the oil, 500 μg/kg.bw of glibenclimide and 2.0 ml/kg.bw of DMSO (Diabetic control group) were given orally to rats in their respective groups after induction with 130 mg/kg.bw of alloxan monohydrate. Results: At 21st day, the glibenclimide treated group and oil extract of petroleum ether and dichloromethane treated groups showed significant reduction (P<0.05) in blood glucose level at 78.00, 51.16 and 77.31% respectively when compared with control that showed 3.25% increase. There was also significant (P<0.05) gain in body weight for both oil treated and glibenclimide groups as compared with diabetic control group. The cholesterol, triglyceride and low density lipoprotein were significantly (P<0.05) reduced in the treated group with high density lipoprotein as compared with diabetic control group. Serum total bilirubin, total protein urea and creatinine of the oil treated groups and glibenclimide were significantly reduced (P<0.05) as compared with diabetic control group. Significant (P<0.05) high activities of liver enzymes AST (57.40±2.53) and ALT (68.94±0.90) with low mean percentage ratio of fresh organs to whole body weight (liver, kidney and spleen). Conclusion: The seed oil of Moringa oleifera Lam. at 2 ml/kg.bw has significant antidiabetic properties on the diabetic rats in addition to improving the biochemical abnormalities arising from the disease.
机译：目的：探讨辣木种子油的抗糖尿病作用。用石油醚和二氯甲烷萃取，然后与格列本脲比较。研究设计：采用实验研究设计。方法：将2.0 ml / kg体重油（kg.bw），500μg/ kg.bw格列本脲和2.0 ml / kg.bw DMSO（糖尿病对照组）口服后分别给予各组大鼠130 mg / kg.bw的四氧嘧啶一水合物诱导。结果：在第21天，格列本脲治疗组和石油醚和二氯甲烷治疗组​​的油提取物与对照组相比，血糖水平分别显着降低（P <0.05），分别为78.00、51.16和77.31％。对照显示出3.25％的增长。与糖尿病对照组相比，油处理组和格列本脲组的体重均显着增加（P <0.05）。与糖尿病对照组相比，高密度脂蛋白治疗组的胆固醇，甘油三酸酯和低密度脂蛋白显着降低（P <0.05）。与糖尿病对照组相比，油处理组和格列本脲的血清总胆红素，总蛋白尿素和肌酐均显着降低（P <0.05）。肝酶AST（57.40±2.53）和ALT（68.94±0.90）的肝酶显着（P <0.05）高活性，而新鲜器官与整个体重（肝脏，肾脏和脾脏）的平均百分率较低。结论：辣木的种子油。 2 ml / kg.bw对糖尿病大鼠具有显着的抗糖尿病作用，此外还改善了由疾病引起的生化异常。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号