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首页> 外文期刊>Journal of Behavioral and Brain Science >Genetic and Demographic Outcomes in a Population of Patients with Headache and Facial Pain
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Genetic and Demographic Outcomes in a Population of Patients with Headache and Facial Pain

机译：头痛和面部疼痛患者人群的遗传和人口统计学结果

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Background: Pharmacogenetics information about cytochrome p450 (CYP450) polymorphism in patients with headaches is limitedly reported. Similarly, the genetic factors linking various headache types and vascular disorders are poorly described. We aimed to characterize the genetic profile of a cohort of headache and facial pain subjects. Methods: Medical records of consecutive headache subjects that underwent PersonaGene~(TM) testing were reviewed. PersonaGene~(TM) panel assessed CYP450, apolipoprotein E (ApoE), methylene tetrahydrofolate reductase (MTHFR), Factor II, Factor V Leiden and Vitamin K epoxide reductase complex subunit 1 (VKORC1). Demographic information, headache diagnosis and genetic profiling were analyzed and compared with data obtained from the general population. Results: Out of 130 headache patients, 91.3% were Caucasian and 70.8% had migraine. Compared to the general Caucasian population, our Caucasian headache patients were significantly different for CYP3A4/A5 and CYP2D6 (p < 0.001) and comparable regarding CYP2C9 and CYPC19. Whereas MTHFR genotype was similar, ApoE and Factor V Leiden were different in headache patients (p = 0.001). Less headache patients showed intermediate sensitivity to warfarin (p = 0.009) based on VQORC1 genotyping. No differences were noticed between migraine and other headache type diagnoses for all the genetic tests. Conclusion: Distinctive profiles for CYP450, ApoE, Factor V Leiden and VQORC1 were observed in our Caucasian headache cohort. These results may impact headache subjects’ pharmacological treatment options and vascular risk ascertainment.
机译：背景：头痛患者中有关细胞色素p450（CYP450）多态性的药物遗传学信息报道很少。同样，关于各种头痛类型和血管疾病的遗传因素也很少描述。我们旨在表征一组头痛和面部疼痛受试者的遗传特征。 方法：回顾接受PersonaGene〜（TM）测试的连续头痛受试者的病历。 PersonaGeneTM小组评估了CYP450，载脂蛋白E（ApoE），亚甲基四氢叶酸还原酶（MTHFR），因子II，因子V Leiden和维生素K环氧还原酶复合物亚基1（VKORC1）。分析了人口统计学信息，头痛诊断和遗传特征，并与从普通人群获得的数据进行了比较。 结果：在130名头痛患者中，白人占91.3％，偏头痛占70.8％。与普通白种人人群相比，我们的白种人头痛患者的CYP3A4 / A5和CYP2D6有显着差异（p <0.001），并且在CYP2C9和CYPC19方面具有可比性。 MTHFR基因型相似，而头痛患者中的ApoE和因子V Leiden不同（p = 0.001）。根据VQORC1基因分型，头痛程度较低的患者对华法林表现出中等敏感性（p = 0.009）。对于所有基因测试，偏头痛诊断与其他头痛类型诊断之间均未发现差异。 结论：在我们的白种人头痛队列中观察到CYP450，ApoE，因子V莱顿和VQORC1的独特特征。这些结果可能会影响头痛受试者的药物治疗选择和血管风险的确定。

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