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首页> 外文期刊>Journal of Behavioral and Brain Science >FMRI and EEG Reactions to Hand Motor Tasks in Patients with Mild Traumatic Brain Injury: Left-Hemispheric Sensitivity to Trauma
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FMRI and EEG Reactions to Hand Motor Tasks in Patients with Mild Traumatic Brain Injury: Left-Hemispheric Sensitivity to Trauma

机译：轻度颅脑损伤患者的FMRI和EEG对手部运动任务的反应：左半球对创伤的敏感性

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Background: Mild traumatic brain injury (mTBI) is one of the most common forms of cerebral pathology in young people and disorders involve dysfunctions in cognitive and motor spheres. We would like to examine the structural and functional alterations of the brain in patients with mTBI while performing hand movements. Methods: Twenty healthy right-handed subjects (age 25.1 ± 3.9) and 10 patients (age 27.9 ± 7.3) with mTBI without hemiparesis participated in the study using functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). FMRI and EEG reactions were analysed during right- and left-hand movements. Results: It was shown that fMRI reactive changes have a larger inter-individual variability of activation during left-hand movements in comparison with right-hand ones in healthy subjects. The TBI patients demonstrated an increase of a diffuse component of fMRI reactive changes compared to healthy people. A greater number of the brain structures was involved, mainly at the subcortical level, mostly in the left hemisphere during right-hand movement. EEG study demonstrated coherence changes for the slow (delta) frequency bands in the left hemisphere, while performing both hand movements. In healthy persons, EEG coherence changes were observed in the fast (alhpa2) frequency band predominantly in contralateral hemispheres, while performing hand movements. Conclusion: So, fMRI and EEG studies revealed the most expressed pathological reactive changes in the left hemisphere and the brain cortical structures during right-hand movements in patients after mTBI. These data allowed us to propose that the younger brain structures were the most sensitive to mTBI.
机译：背景：轻度创伤性脑损伤（mTBI）是年轻人最常见的脑病理形式之一，而疾病涉及认知和运动领域的功能障碍。我们希望在进行手部运动时检查mTBI患者大脑的结构和功能改变。 方法：20名健康右撇子受试者（25.1±3.9岁）和10名无偏瘫的mTBI患者（27.9±7.3岁）使用功能磁共振成像（fMRI）和脑电图（EEG）参加了研究。在右手和左手运动期间分析了FMRI和EEG反应。 结果：研究表明，与健康受试者的右手相比，左手运动期间fMRI反应性变化具有更大的个体间激活差异。与健康人相比，TBI患者表现出fMRI反应性改变的弥散成分增加。大脑活动涉及的大脑结构更多，主要是在皮层下水平，主要是在右手运动时左半球。脑电图研究表明，左手半球中慢速（δ）频段的相干性变化同时执行了两只手的运动。在健康的人中，在进行手部运动时，主要在对侧半球的快速（alhpa2）频段观察到EEG相干性变化。 结论：因此，fMRI和EEG研究显示mTBI后患者右手运动期间左半球和大脑皮层结构的病理反应最明显。这些数据使我们提出，年轻的大脑结构对mTBI最敏感。

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