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首页> 外文期刊>Journal of Behavioral and Brain Science >Energy Aspects of Sodium Thiopental Action on Nervous Activity
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Energy Aspects of Sodium Thiopental Action on Nervous Activity

机译：硫喷妥钠钠对神经活动的能量影响

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Sodium thiopental, used in a narcotic dose, makes it possible to identify the nervous processes that underlie consciousness and establish the causes of its disorder. When studying the cortical EEG activity, the impulses of individual nerve cells and the electromyographic activity of the muscles of the forelimb, it was found that thiopental blocks a number of neuronal reactions requiring energy support: tonic activating reactions to acetylcholine, applied to neurons, cease; the rate of spontaneous neuronal activity drops; the stage of non-specific activation in response to electrocutaneous stimulation disappears. So, thiopental blocks consciousness by significant limitation of the brain energy metabolism. This results in a loss of the adaptive function of the central nervous system. At the same time, glutamatergic excitation, the formation of which does not depend on energy support, is resistant to the action of thiopental. The blocking of the brain’s energy supply caused by thiopental, in accordance with its depth, develops in two stages—hypoxic and narcotic. The hypoxic stage is accompanied by hyperactivity in the nervous system, which is manifested by epileptiform discharges on the EEG and powerful unmotivated movement; the narcotic stage is associated with blockade of motor activity and flattening of EEG oscillations. The post-narcotic state associated with the consequence of the hypoxic effect of thiopental leads to the loss of ionic homeostasis and is accompanied by a steady drop in the amplitude of cortical neuron spikes.
机译：以麻醉剂量使用的硫喷妥钠使人们有可能识别意识基础的神经过程并确定其失调的原因。在研究皮层脑电图的活动，单个神经细胞的冲动和前肢肌肉的肌电图活动时，发现硫喷妥钠阻断了许多需要能量支持的神经元反应：对乙酰胆碱的强直激活反应，应用于神经元的活动停止了。 ;自发神经元活动率下降;响应电皮肤刺激的非特异性激活阶段消失了。因此，硫喷妥钠通过明显限制脑能量代谢来阻止意识。这导致中枢神经系统的适应性功能丧失。同时，其形成形式不依赖于能量支持的谷氨酸能激发的兴奋剂对硫喷妥特具有抗性。硫喷妥钠对人脑的能量供应依其深度而定，分为两个阶段：低氧和麻醉。缺氧阶段伴随着神经系统过度活跃，表现为脑电图上的癫痫样放电和有力的无动力运动。麻醉阶段与运动活动受阻和脑电图振荡变平有关。麻醉后状态与硫喷妥钠的低氧作用相关，导致离子体内稳态的丧失，并伴有皮质神经元尖峰幅度的稳定下降。

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