• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Behavioral and Brain Science >Individual Differences in Stress Responsiveness of the Hypothalamic-Pituitary-Adrenal Axis and Its Vasopressinergic Regulation in Old Monkeys
【24h】

Individual Differences in Stress Responsiveness of the Hypothalamic-Pituitary-Adrenal Axis and Its Vasopressinergic Regulation in Old Monkeys

机译：下猴子的下丘脑-垂体-肾上腺轴应激反应的个体差异及其对血管加压的调节

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Stress adaptation is fundamental for health, and the hypothalamic-pituitary-adrenal axis (HPA) is one of its main mechanisms. Considerable data indicate that arginine vasopressin (AVP) related disturbances of stress adaptation can occur with aging. However, most studies of such kind have been performed on rodents, give contradictory results and fail to consider individual characteristics of the animals. The purpose of this study was to investigate individual HPA responsiveness to acute stress and its vasopressinergic regulation in old female rhesus monkeys that differ in their behavioral responses to stress. Animals with depression-like or anxiety-like behavior (DAB) responded with higher plasma levels of ACTH and AVP, lower levels of corticosteroids and higher cortisol/DHEAS molar ratios to restraint stress and to insulin-induced hypoglycemia compared with animals with healthy adaptive behavior. AVP and ACTH dynamics were closely correlated in most animals. AVP treatment produced differences in HPA responses similar to those produced by the stressors. The ACTH response to hypoglycemic stress in the DAB animal with highest HPA responsiveness was dramatically reduced by prior administration of a V1b receptor antagonist. These results suggest that the dysfunctions of HPA observed in old animals with DAB are caused by increased tone of the vasopressinergic system in regulation of HPA stress reactivity.
机译：压力适应对健康至关重要，下丘脑-垂体-肾上腺轴（HPA）是其主要机制之一。大量数据表明，精氨酸加压素（AVP）相关的压力适应障碍会随着年龄的增长而发生。但是，大多数这类研究都是在啮齿动物上进行的，结果相矛盾，而且没有考虑动物的个体特征。这项研究的目的是调查个体HPA对老年雌性恒河猴的急性应激反应及其对加压素的调节作用，这些猕猴对应激的行为反应有所不同。与具有健康适应行为的动物相比，具有抑郁样或焦虑样行为（DAB）的动物对血浆ACTH和AVP含量较高，皮质类固醇水平较低和皮质醇/ DHEAS摩尔比更高，从而能够抑制应激和胰岛素诱发的低血糖。在大多数动物中，AVP和ACTH动力学密切相关。 AVP处理产生的HPA反应差异与压力源产生的差异相似。预先给予V1b受体拮抗剂可显着降低具有最高HPA反应性的DAB动物对低血糖应激的ACTH反应。这些结果表明，在患有DAB的老年动物中观察到的HPA功能障碍是由调节HPA应激反应性的加压素系统的张力增加引起的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号