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首页> 外文期刊>Journal of Behavioral and Brain Science >Clustered c-Fos Activation in Rat Hippocampus at the Acquisition Stage of Appetitive Instrumental Learning
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Clustered c-Fos Activation in Rat Hippocampus at the Acquisition Stage of Appetitive Instrumental Learning

机译：参与性器乐学习习得阶段大鼠海马中的群集c-Fos激活

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To address the issue of how hippocampal neurons are involved into learning progress, we studied c-Fos expression in rat hippocampal subfields at different stages of appetitive instrumental learning. To model the first stage of learning, we pre-trained animals to approach the lever to obtain the food, and then made this behavior ineffective by not reinforcing it during the last session (“mismatch” group). Another group just acquired lever-pressing behavior at that day (“acquisition” group). Animals of the third group performed this well-trained behavior (“performance” group). The number of Fos-positive neurons in all hippocampal regions of the “mismatch” group animals was higher than in the ones of the home cage control group animals. The number of Fos-positive neurons was increased in CA1 and CA3 areas, but not in the dentate gyrus of both the “acquisition” and “performance” group animals as compared with the control group. We also found segmented c-Fos expression, which was more evident in “acquisition” group animals. Thus, our results suggest that during the first (mismatch) stage of learning hippocampal neurons are activated in an equally distributed manner. The following clustered pattern of activated CA1 neurons during the acquisition stage may reflect specialization of these neurons in respect to the specific lever-pressing behavior.
机译：为了解决海马神经元如何参与学习进展的问题，我们研究了在有工具学习的不同阶段大鼠海马亚区中c-Fos的表达。为了模拟学习的第一阶段，我们对动物进行了预训练，使其接近获取食物的杠杆，然后通过在上一阶段（“不匹配”组）不加重行为来使这种行为无效。当天，另一个小组刚刚获得了压杆行为（“收购”小组）。第三组动物表现出这种训练有素的行为（“表现”组）。在“不匹配”组动物的所有海马区中，Fos阳性神经元的数量高于家笼对照组动物的数量。与对照组相比，CA1和CA3区的Fos阳性神经元数量增加，但“习得”和“表现”组动物的齿状回均没有增加。我们还发现了分段的c-Fos表达，这在“获得”组动物中更为明显。因此，我们的结果表明，在学习的第一个（不匹配）阶段，海马神经元以均等分布的方式被激活。在获取阶段，激活的CA1神经元的以下聚类模式可能反映了这些神经元在特定的杠杆按压行为方面的特殊性。

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