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首页> 外文期刊>Journal of Behavioral and Brain Science >Dual PINK Mutant and Aβ42-Dependent Lifespan Shorten and Flight Impairment in Transgenic Drosophila Partially Alleviates by a Lactococcus lactis Supplemented Diet
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Dual PINK Mutant and Aβ42-Dependent Lifespan Shorten and Flight Impairment in Transgenic Drosophila Partially Alleviates by a Lactococcus lactis Supplemented Diet

机译：PINK突变体和Aβ42依赖的双寿命缩短和转基因果蝇中的飞行障碍部分由乳酸乳球菌补充饮食部分缓解

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Oxidative stress has been strongly related with Parkinson disease (PD) and Alzheimer disease pathogenesis. We determined the effects of Lactococcus lactis (LAL) supplementation on the generated loss-of-function mutants of PINK1 B9, an AR-JP-linked gene and Aβ42 induced phenotypes in a Drosophila melanogaster model of PD/AD. Enhanced mutant PINK1 B9 and Aβ42 expression in D. melanogaster dopaminergic (DA) neurons can curtail lifespan, flight muscle accompanied by locomotive defects and we have observed longevity methods to assay the effects of LAL on D. melanogaster survival. Furthermore, flies expressing mutant PINK1 B9 and Aβ42 in their brain fed LAL had up to the two weeks, or 25%, greater median lifespan than those fed a standard sucrose diet. In addition, LAL improved mutant PINK1 B9 and Aβ42-induced flight impairments in the Drosophila wing. Our microscopy analyses revealed that individuals fed LAL had improved atypical ommatidia as well as an increased thirteen percentage of flight ability than those fed a control diet. We propose that LAL, rich in naturally occurring probiotics and antioxidants, promotes the survival of neurons in brain and wing muscle tissues with increased levels of mutant PINK1 B9 and Aβ42 via a protective cell survival mechanism.
机译：氧化应激与帕金森氏病（PD）和阿尔茨海默氏病的发病机理密切相关。我们确定了乳酸乳球菌（LAL）补充对PD / AD的果蝇黑腹果蝇模型中PINK1 B9，AR-JP连锁基因和Aβ42诱导表型产生的功能丧失突变体的影响。黑腹果蝇多巴胺能（DA）神经元中增强的突变体PINK1 B9和Aβ42表达可以缩短寿命，伴随机车缺陷的飞行肌肉，并且我们观察到了长寿方法来测定LAL对黑腹果蝇存活的影响。此外，与喂食标准蔗糖饮食的苍蝇相比，在喂食LAL的大脑中表达突变体PINK1 B9和Aβ42的苍蝇的中位寿命长达两周，即25％。此外，LAL改善了果蝇翅中的突变PINK1 B9和Aβ42诱导的飞行障碍。我们的显微镜分析表明，与对照饮食相比，饲喂LAL的个体的非典型眼泪得到改善，飞行能力提高了13％。我们提出，富含天然益生菌和抗氧化剂的LAL可以通过保护性细胞存活机制提高PINK1 B9和Aβ42突变体水平，从而促进大脑和翼肌组织中神经元的存活。

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