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首页> 外文期刊>Journal of atherosclerosis and thrombosis. >Newly Developed Rat Model of Chronic Kidney Disease–Mineral Bone Disorder
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Newly Developed Rat Model of Chronic Kidney Disease–Mineral Bone Disorder

机译：新开发的慢性肾脏病大鼠模型-矿物质骨疾病

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Aim : Chronic kidney disease–mineral bone disorder (CKD–MBD) is associated with all-cause and cardiovascular morbidity and mortality in patients with CKD. Thus, elucidating its pathophysiological mechanisms is essential for improving the prognosis. We evaluated characteristics of CKD–MBD in a newly developed CKD rat model. Methods : We used male Sprague–Dawley (SD) rats and spontaneously diabetic Torii (SDT) rats, which are used as models for nonobese type 2 diabetes. CKD was induced by 5/6 nephrectomy (Nx). At 10 weeks, the rats were classified into six groups and administered with a vehicle or a low- or high-dose paricalcitol thrice a week. At 20 weeks, the rats were sacrificed; blood and urinary biochemical analyses and histological analysis of the aorta were performed. Results : At 20 weeks, hemoglobin A1c (HbA1c) levels, blood pressure, and renal function were not significantly different among the six groups. Serum calcium and phosphate levels tended to be higher in SDT-Nx rats than in SD-Nx rats. The urinary excretion of calcium and phosphate was significantly greater in SDT-Nx rats than in SD-Nx rats. After administering paricalcitol, serum parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) levels were significantly higher in SDT-Nx rats than in SD-Nx rats. The degree of aortic calcification was significantly more severe and the aortic calcium content was significantly greater in SDT-Nx rats than in SD-Nx rats. Conclusions : We suggest that our new CKD rat model using SDT rats represents a useful CKD-MBD model, and this model was greatly influenced by paricalcitol administration. Further studies are needed to clarify the detailed mechanisms underlying this model.
机译：目的：慢性肾脏疾病-矿物质骨疾病（CKD-MBD）与CKD患者的全因和心血管疾病发病率及死亡率有关。因此，阐明其病理生理机制对于改善预后至关重要。我们评估了新开发的CKD大鼠模型中CKD–MBD的特征。方法：我们使用雄性Sprague-Dawley（SD）大鼠和自发性糖尿病Torii（SDT）大鼠作为非肥胖2型糖尿病模型。 CKD由5/6肾切除术（Nx）诱导。在第10周时，将大鼠分为六组，并每周三次接受媒介物或低剂量或高剂量的paricalcitol。在20周时，处死大鼠。进行血液和尿液生化分析以及主动脉的组织学分析。结果：20周时，六组患者的血红蛋白A1c（HbA1c）水平，血压和肾功能无显着差异。 SDT-Nx大鼠的血清钙和磷酸盐水平往往高于SD-Nx大鼠。 SDT-Nx大鼠的尿钙和磷酸盐排泄量显着高于SD-Nx大鼠。服用paricalcitol后，SDT-Nx大鼠的血清甲状旁腺激素（PTH）和成纤维细胞生长因子23（FGF23）的水平显着高于SD-Nx大鼠。与SD-Nx大鼠相比，SDT-Nx大鼠的主动脉钙化程度明显更严重，主动脉钙含量明显更高。结论：我们建议我们使用SDT大鼠的新CKD大鼠模型代表了一种有用的CKD-MBD模型，该模型受到paricalcitol的使用影响很大。需要进一步研究以阐明该模型的详细机制。

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