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Sex Influence on the Formation of Alcohol Preference and Behavior in Rats during the Long-Term Caffeine and Ethanol Intake

机译:长期摄入咖啡因和乙醇期间性别对大鼠饮酒偏好和行为的影响

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Last years the intake of energy drinks (drinks containing caffeine and alcohol) both in young men and women has been increased. However the investigators do not pay attention to the analysis of gender differences. The goal of the study was the investigation of ethanol and caffeine influence on the alcohol preference formation and behavior in male and female rats under the conditions of long-term experiment. It has been found that six month intake of caffeine, ethanol and their combination has led to the increase of alcohol preference both in male and female rats. Alcohol preference was formed earlier in rats consumed combination of caffeine with ethanol, later on in rats consumed ethanol. In animals consumed caffeine the strong alcohol preference did not form up to the end of the experiment. Alcohol preference was higher in female rats consuming caffeine with ethanol and pure ethanol solution compared to male rats. .Behavioral activity significantly increased in females consumed caffeine and caffeine with ethanol, compared to animals received ethanol and controls. Similar tendency was observed in male rats. The anxiety level was significantly higher in females rats in all experimental groups compared to controls, while males did not demonstrate increased anxiety.
机译:近年来,无论男女,能量饮料(含有咖啡因和酒精的饮料)的摄入量都有所增加。但是,研究人员并不关注性别差异的分析。该研究的目的是研究长期实验条件下乙醇和咖啡因对雄性和雌性大鼠酒精偏好形成和行为的影响。已经发现,六个月摄入咖啡因,乙醇及其混合物导致雄性和雌性大鼠的酒精偏好增加。在摄入咖啡因与乙醇的大鼠中,较早形成了酒精偏好,后来在摄入乙醇的大鼠中,形成了酒精偏好。在食用咖啡因的动物中,直到实验结束才形成强烈的酒精偏好。与雄性大鼠相比,饮用咖啡因和乙醇及纯乙醇溶液的雌性大鼠对酒精的偏爱更高。与接受乙醇和对照组的动物相比,食用咖啡因和咖啡因的雌性动物的行为活性显着增加。在雄性大鼠中观察到类似的趋势。与对照组相比,所有实验组的雌性大鼠的焦虑水平均明显高于对照组,而雄性则没有显示焦虑增加。

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