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首页> 外文期刊>Journal of Allergy >The Compatible Solute Ectoine Reduces the Exacerbating Effect of Environmental Model Particles on the Immune Response of the Airways
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The Compatible Solute Ectoine Reduces the Exacerbating Effect of Environmental Model Particles on the Immune Response of the Airways

机译：兼容的溶质电子烟碱可降低环境模型颗粒对气道免疫反应的加剧作用

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Exposure of humans to particulate air pollution has been correlated with the incidence and aggravation of allergic airway diseases. In predisposed individuals, inhalation of environmental particles can lead to an exacerbation of immune responses. Previous studies demonstrated a beneficial effect of the compatible solute ectoine on lung inflammation in rats exposed to carbon nanoparticles (CNP) as a model of environmental particle exposure. In the current study we investigated the effect of such a treatment on airway inflammation in a mouse allergy model. Ectoine in nonsensitized animals significantly reduced the neutrophilic lung inflammation after CNP exposure. This effect was accompanied by a reduction of inflammatory factors in the bronchoalveolar lavage. Reduced IL-6 levels in the serum also indicate the effects of ectoine on systemic inflammation. In sensitized animals, an aggravation of the immune response was observed when animals were exposed to CNP prior to antigen provocation. The coadministration of ectoine together with the particles significantly reduced this exacerbation. The data indicate the role of neutrophilic lung inflammation in the exacerbation of allergic airway responses. Moreover, the data suggest to use ectoine as a preventive treatment to avoid the exacerbation of allergic airway responses induced by environmental air pollution.
机译：人体暴露于颗粒空气污染已与过敏性气道疾病的发生和加剧相关。在易感人群中，吸入环境颗粒可导致免疫反应加剧。先前的研究表明，相容性溶质外啡肽对暴露于碳纳米颗粒（CNP）的大鼠的肺部炎症具有有益作用，可作为环境颗粒暴露的模型。在当前的研究中，我们调查了这种治疗对小鼠过敏模型中气道炎症的影响。在未致敏动物中，Ectoine可显着减少CNP暴露后的嗜中性肺炎。该作用伴随着支气管肺泡灌洗液中炎性因子的减少。血清中IL-6水平的降低也表明了ectoine对全身性炎症的影响。在致敏动物中，在抗原激发前将动物暴露于CNP时观察到免疫反应加剧。依他汀与颗粒的共同给药显着降低了这种恶化。数据表明中性粒细胞肺炎症在过敏性气道反应加重中的作用。此外，数据建议使用果胶作为预防性治疗，以避免因环境空气污染引起的过敏性气道反应加剧。

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