...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Behavioral and Brain Science >Cisplatin-Induced Posterior Reversible Encephalopathy Syndrome—Brief Report and Review of the Literature
【24h】

Cisplatin-Induced Posterior Reversible Encephalopathy Syndrome—Brief Report and Review of the Literature

机译：顺铂诱导的后可逆性脑病综合征—简要报告和文献复习

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cisplatin is one of the most broadly used chemotherapeutic agents. Several central nervous system toxicities have been attributed to this agent, among which is a rare clinicoradiological condition referred to as posterior reversible leukoen-cephalopathy syndrome (PRES) or reversible posterior leukoencephalopathy syndrome (RPLS). PRES is characterized by subacute onset of headache, visual disturbances, confusion, seizures and rarely, coma. This usually reversible syn-drome was associated in the past mainly with hypertension. Several reports have associated the syndrome with several immunosuppressive and chemotherapeutic agents suggesting a disruption of the blood brain barrier due to direct damage to the endothelium and vasogenic edema. This syndrome is readily diagnosed with Computed Tomography (CT) or Magnetic resonance imaging (MRI) studies and quick withdrawal of the causative agent in conjunction with supportive care including rapid hypertension control and reduction of elevated intracranial pressure when needed, usually reverse the neurological symptoms with minimal or even no sequela within several days. In this brief report and review of the literature we describe two cases of PRES in two female patients that occurred a few days after receiving Cisplatin-based chemotherapy. We discuss the clinical presentation, diagnosis and treatment of this syndrome by reviewing the literature. The escalating number of clinical reports of PRES merit further studies of the mechanism of toxicity, appropriate treatment and awareness of physicians to this life threatening entity
机译：顺铂是使用最广泛的化学治疗剂之一。该药物归因于几种中枢神经系统毒性，其中一种罕见的临床放射学疾病称为后可逆性白脑脑病综合征（PRES）或可逆性后部白脑脑病综合征（RPLS）。 PRES的特征是亚急性发作的头痛，视力障碍，意识混乱，癫痫发作和极少的昏迷。在过去，这种通常可逆的综合征主要与高血压有关。有几篇报道将该综合征与几种免疫抑制剂和化学治疗剂相关联，表明由于对内皮的直接损害和血管性水肿，血脑屏障被破坏。通过计算机断层扫描（CT）或磁共振成像（MRI）研究可轻松诊断出该综合征，并迅速撤离病因并结合支持治疗，包括快速控制高血压和在需要时降低颅内压，通常可逆转神经系统症状。几天内很少或什至没有后遗症。在这份简短的报告和文献回顾中，我们描述了两名女性患者中的两例PRES，这些患者在接受基于顺铂的化疗后几天发生。我们通过回顾文献讨论该综合征的临床表现，诊断和治疗。越来越多的PRES临床报告值得进一步研究毒性机制，适当的治疗方法以及医生对这一威胁生命的实体的认识

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号