...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Behavioral and Brain Science >Effects of 17β-Estradiol on Cognitive Performance of Ovariectomized Female Rats Exposed to Space Radiation
【24h】

Effects of 17β-Estradiol on Cognitive Performance of Ovariectomized Female Rats Exposed to Space Radiation

机译：17β-雌二醇对卵巢切除去卵巢雌性大鼠空间辐射认知能力的影响

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

On exploratory class missions to other planets astronauts will be exposed to types and doses of radiation that are not experienced in low earth orbit. While it is likely that the crew will consist of both male and female astronauts, there has been little research on the effects of exposure to space radiation on central nervous system function and cognitive performance in female subjects. Because estrogen can function as a neuroprotectant, the present experiments were designed to evaluate whether or not the presence or absence of estrogen at the time of irradiation would affect the susceptibility to the neurocognitive effects of exposure to 56Fe particles in female rats. Capsules containing 17β-estradiol or vehicle were implanted in ovariectomized rats three days prior to exposure 56Fe particles (50 - 200 cGy, 1000 MeV). Cognitive performance was evaluated using novel object recognition memory to measure learning and memory and operant responding on an ascending fixed-ratio schedule to measure changes in motivation and in the responsiveness to environmental contingencies. The results indicated the estrogen does not function as a neuroprotectant to minimize the cognitive effects of exposure to 56Fe particles. However, the presence/absence of estrogen at the time of irradiation could modulate the responsiveness of the subject to the disruptive effects of exposure to HZE particles on the performance of specific cognitive tasks.
机译：在对其他行星进行的探索性飞行任务中，宇航员将受到低地球轨道上未经历的辐射类型和剂量的影响。尽管机组人员可能由男性和女性宇航员组成，但很少有人研究暴露于空间辐射对女性受试者中枢神经系统功能和认知能力的影响。因为雌激素可以起到神经保护剂的作用，所以设计本实验是为了评估照射时雌激素的存在与否是否会影响雌性大鼠接触56Fe颗粒对神经认知作用的敏感性。在暴露56Fe颗粒（50-200 cGy，1000 MeV / n）之前三天，将含有17β-雌二醇或赋形剂的胶囊植入卵巢切除的大鼠中。使用新颖的物体识别记忆来评估学习和记忆，并以固定比率递增的操作员响应来评估动机和对环境突发事件的响应，从而评估认知能力。结果表明，雌激素不能作为神经保护剂来使暴露于56Fe颗粒的认知作用最小化。然而，照射时是否存在雌激素可能会调节受试者对暴露于HZE颗粒对特定认知任务的破坏作用的反应性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号