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首页> 外文期刊>Journal of Applied Life Sciences International >Infectious Differences between the Dermatophytes- Induced Dermatophytosis in Wistar Rat
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Infectious Differences between the Dermatophytes- Induced Dermatophytosis in Wistar Rat

机译：Wistar大鼠中皮肤癣菌引起的皮肤癣菌病之间的感染差异

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Aims: This study investigates the infectious differences between the two dermatophytes Trichophyton rubrum ( T. rubrum ) and Epidermophyton floccosum ( E. floccosum ), and analysed their growing effects and morphology on the skin of Wistar rats. Study Design: The histology and histochemistry studies were investigated. Methodology: Nine animals were used and divided into 3 equal groups. Group A was the control (not infected), group B was infected with T. rubrum and group C was infected with E. floccosum. 2 ml of washed fungal organisms were spilled on shaved, cleaned and disinfected skin of the Wistar rats with cotton swab saturated with 70% ethanol separately. The dermatophytes were allowed to incubate with noticeable changes when physically observed. Animals were sacrificed using cervical dislocation under chloroform anaesthesia, after 12 days of infection for both histological and histochemical studies. Results: The skin of the animals were observed with the falling of furs on the skin of the Wistar rats infected with different organisms compare with the control group. The histochemical studies of melanoaldehyde (MDA), superioxide dismutase (SOD) and total protein (T.P) were carried out with T. rubrum infected group observed to have highest level of SOD that is 778.02±4.00 as against 741.01±4.00 of E. floccosum , which suggested some protecting reactions in the skin against reactive oxygen species. Also, the total protein level of the infected groups increased slightly compare to the control group. The little increase in the level of MDA was observed in E. floccosum infected group. The histological appearance in the cellular architecture and arrangement in group B compared with group C with obvious differences observed. Thus, T. rubrum infected group digested keratin more than E. floccosum -infected group, and may be as a result of serious invasion of the epidermis and its rete ridges by the fungi. Conclusion: It can therefore be concluded that, T. rubrum is more infectious in terms on its commonest and keratin digestion when compared with E. floccosum.
机译：目的：本研究调查了两种皮肤癣菌毛癣菌（T. rubrum）和表皮絮状絮（E. floccosum）之间的传染性差异，并分析了它们对Wistar大鼠皮肤的生长作用和形态。研究设计：对组织学和组织化学研究进行了调查。方法：使用九只动物，分为3组。 A组为对照组（未感染），B组感染了红曲霉，C组感染了絮状大肠杆菌。用分别用70％乙醇饱和的棉签将2 ml洗涤过的真菌生物体洒在Wistar大鼠的剃毛，清洁和消毒的皮肤上。物理观察时，允许皮肤癣菌以明显的变化进行孵育。感染12天后，在氯仿麻醉下使用颈脱位法处死动物，用于组织学和组织化学研究。结果：与对照组相比，观察到动物皮肤的皮毛掉落，感染了不同生物体的Wistar大鼠的皮肤脱落。组织学研究了黑三叶草感染组的黑素醛（MDA），超氧化物歧化酶（SOD）和总蛋白（TP），观察到其最高SOD水平为778.02±4.00，而絮状大肠杆菌为741.01±4.00。 ，建议在皮肤中针对活性氧进行一些保护性反应。而且，与对照组相比，感染组的总蛋白水平略有增加。在絮状大肠杆菌感染组中，MDA水平几乎没有增加。与C组相比，B组的细胞结构和排列的组织学外观明显不同。因此，红曲霉感染组消化的角蛋白多于絮状大肠杆菌感染的组，这可能是真菌严重侵害表皮及其网纹的结果。结论：因此，可以得出结论，与絮状大肠杆菌相比，毛状锥虫在其最常见的和角蛋白消化方面更具感染力。

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