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首页> 外文期刊>Journal of atherosclerosis and thrombosis. >Upregulation of Monocyte Tissue Factor Activity is Significantly Associated with Carotid Intima-Media Thickness in Patients with Metabolic Syndrome
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Upregulation of Monocyte Tissue Factor Activity is Significantly Associated with Carotid Intima-Media Thickness in Patients with Metabolic Syndrome

机译：单核细胞组织因子活性的上调与代谢综合征患者的颈动脉内膜中层厚度明显相关。

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Aims: Metabolic syndrome (MS) represents a cluster of cardiovascular risk factors and an increased risk of cardiovascular events. The carotid intima-media thickness (CIMT) is correlated with coronary and carotid atherosclerosis, and is a significant predictor of cardiovascular events. Tissue factor (TF) is an initiator of the extrinsic coagulation cascade and is expressed on peripheral blood monocytes and macrophages in atherosclerotic plaques. TF plays important roles in both thrombosis and atherosclerosis. No study has investigated the relationship between monocyte TF activity and CIMT in MS patients. Methods: Peripheral blood mononuclear cells (PBMCs) were collected from 39 normal subjects and 110 patients with MS. The procoagulant activity (PCA) in monocytes was measured using a one-stage clotting assay and is expressed as the mean±SD (mU TF/106 PBMCs). Results: The PCA in monocytes in MS patients was significantly higher than in normal subjects (86.2 ±69.5 vs. 52.4±9.9 mU TF/106 PBMCs, p < 0.001). In multivariate analysis, patient age (β coefficient= 0.373, p < 0.001), high-density lipoprotein cholesterol (β coefficient=?0.307, p = 0.001) and PCA (β coefficient= 0.422, p =0.002) were each significantly and independently associated with CIMT. Conclusions: These data indicate that the upregulation of monocyte TF activity is significantly associated with CIMT in MS patients.
机译：目的：代谢综合征（MS）代表一系列心血管危险因素和心血管事件风险增加。颈动脉内中膜厚度（CIMT）与冠状动脉和颈动脉粥样硬化相关，并且是心血管事件的重要预测指标。组织因子（TF）是外在凝血级联反应的引发剂，在动脉粥样硬化斑块的外周血单核细胞和巨噬细胞上表达。 TF在血栓形成和动脉粥样硬化中都起着重要作用。尚无研究调查MS患者单核细胞TF活性与CIMT之间的关系。方法：从39名正常人和110名MS患者中收集外周血单个核细胞（PBMC）。使用一级凝血测定法测量单核细胞中的促凝血活性（PCA），并表示为平均值±SD（mU TF / 10 6 PBMC）。结果：MS患者单核细胞的PCA明显高于正常受试者（86.2±69.5 vs. 52.4±9.9 mU TF / 10 6 PBMC，p <0.001）。在多变量分析中，患者年龄（β系数= 0.373，p <0.001），高密度脂蛋白胆固醇（β系数=？0.307，p = 0.001）和PCA（β系数= 0.422，p = 0.002）分别显着且独立与CIMT相关联。结论：这些数据表明，MS患者单核细胞TF活性的上调与CIMT显着相关。

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