...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Behavioral and Brain Science >Microinjection of Ghrelin into the Ventral Tegmental Area Potentiates Cocaine-Induced Conditioned Place Preference
【24h】

Microinjection of Ghrelin into the Ventral Tegmental Area Potentiates Cocaine-Induced Conditioned Place Preference

机译：Ghrelin显微注射到腹侧被盖区可增强可卡因诱导的条件性位置偏爱

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Prior work has shown that systemic cocaine pretreatment augments cocaine conditioned place preference (CPP) in rats. In contrast, ghrelin receptor antagonism attenuates cocaine and amphetamine-induced CPP. In order to further investigate ghrelin’s role in dopamine-mediated reward, the present report examined whether pretreament with ghrelin, administered directly into the ventral tegmental area (VTA) of the midbrain, would potentiate the rewarding properties of cocaine as measured by CPP. Adult male Sprague-Dawley rats were given access to either side of the CPP chamber in order to determine initial side preferences. The rats were then restricted to either their non-preferred or preferred side over the course of conditioning which lasted for a total of 16 consecutive days. This was followed by a final test day to then reassess preference. On days where rats were confined to their non-preferred side, ghrelin (30-300 pmol) and cocaine (0.625-10 mg/kg IP) were administered immediately prior to the conditioning trial. On alternate days rats were treated with vehicle and placed into what was initially determined to be their preferred side. CPP was calculated as the difference in percentage of total time spent in the treatment-paired compartment during the post-conditioning session and the pre-conditioning session. Our results indicated that both cocaine and ghrelin elicited CPP and that ghrelin pretreatment potentiated the effect of cocaine on place preference. Overall, these findings provide additional support for the argument that ghrelin signaling within the VTA enhances the rewarding effects of psychostimulant compounds.
机译：先前的工作表明，全身可卡因预处理可增加大鼠中的可卡因条件位置偏爱（CPP）。相反，ghrelin受体拮抗作用减弱了可卡因和苯丙胺诱导的CPP。为了进一步研究生长素释放肽在多巴胺介导的奖赏中的作用，本报告检查了用生长素释放肽预治疗是否直接施用于中脑腹侧被盖区（VTA），可增强可卡因的有益特性（通过CPP评估）。成年雄性Sprague-Dawley大鼠可以进入CPP腔室的任何一侧，以确定初始的一侧偏爱。然后在持续总共16天的调节过程中，将大鼠限制在其非优选或优选的一侧。接下来是最后的测试日，然后重新评估偏好。在大鼠局限于非优选侧的那几天，在调理试验之前立即施用生长素释放肽（30-300 pmol）和可卡因（0.625-10 mg / kg IP）。在隔日，将大鼠用赋形剂处理，并置于最初确定为它们偏爱的一侧。 CPP计算为调理后阶段和调理前阶段在治疗配对隔间中花费的总时间百分比。我们的结果表明，可卡因和ghrelin均引起CPP，而ghrelin预处理增强了可卡因对位置偏好的影响。总体而言，这些发现为VTA内生长素释放肽信号传导增强精神刺激性化合物的奖励作用提供了支持。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号