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首页> 外文期刊>Journal of Behavioral and Brain Science >Effect of BDNF and Adipose Derived Stem Cells Transplantation on Cognitive Deficit in Alzheimer Model of Rats
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Effect of BDNF and Adipose Derived Stem Cells Transplantation on Cognitive Deficit in Alzheimer Model of Rats

机译：BDNF和脂肪干细胞移植对阿尔茨海默病模型大鼠认知功能障碍的影响

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In this study, the potential for recovery mediated by co-treatment of brain-derived neurotrophic factor (BDNF) and adipose tissue derived stem cells (ASCs) on functional recovery after Ibotenic acid (Ibo) lesion of the nucleus basalis magnocellularis (NBM) was examined. Ibotenic acid was injected bilaterally into the NBM of experimental rats, then the animals received treatments as follows: ASCs (500 × 103), BDNF (5 ug/ul) and a combination of BDNF and ASCs. Two months after the treatment, cognitive recovery was assessed by the Morris water-maze. These results showed that ASCs transplantation may have therapeutic value in disease and conditions that result in memory loss, and co-treatment with BDNF doesn’t offer more efficacious cognitive function.
机译：在这项研究中，由脑源性神经营养因子（BDNF）和脂肪组织衍生干细胞（ASCs）共同治疗所介导的恢复潜力，可能是对基底大肌核（NBM）的伊波酸（Ibo）损伤后功能恢复的影响。检查。双向向实验大鼠的NBM中注射艾波酸，然后对动物进行如下处理：ASC（500×103），BDNF（5 ug / ul）以及BDNF和ASC的组合。治疗后两个月，通过莫里斯水迷宫评估认知恢复。这些结果表明，ASCs移植可能对导致记忆力丧失的疾病和病症具有治疗价值，而与BDNF的联合治疗不能提供更有效的认知功能。

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