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首页> 外文期刊>Journal of Behavioral and Brain Science >Human-Related Emotional Stimuli Can Cause a Hippocampal and Thalamic Over-Response in People with Unstable Personalities
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Human-Related Emotional Stimuli Can Cause a Hippocampal and Thalamic Over-Response in People with Unstable Personalities

机译：与人相关的情绪刺激可导致人格不稳定的人的海马和丘脑过度反应

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Hippocampus is crucial for the formation of emotional memory. We found the relationship between hippocampal responses to emotional stimuli and the mental stabilities of people in our preliminary study. In this study, we have also evaluated how the emotional stimuli would affect amygdala and thalamus in the brain, and how the personality stabilities could relate to the responses in the brain using functional magnetic resonance imaging (fMRI). We evaluated the subjects’ personality features with the Yatabe-Guilford Personality Test (Y-G test) and psychosomatic symptoms with the Cornell Medical Index (CMI). The subjects were categorized into the mentally stable group and the mentally unstable group according to the total scores of the Y-G test and the CMI. The brain functional responses under emotional stimuli were measured using fMRI. The region of interest (ROI) analysis was performed to abstract significant changes in order to compare responses among the different emotional stimuli. We conducted the regression analysis to abstract the relationship between the mean % signal change from fMRI and the personality stability. The fMRI results showed that the hippocampus, thalamus, and right amygdala activities under the human relationship stimuli increased with ascending value of mental instability. Our findings suggest that the memory process in the hippocampus and the threat alarm system in the thalamus under the human-related stimuli crucially influence the emotional reaction of mentally unstable people. These processes in the brain would affect the event that stresses on human relationships that often cause people to suffer from mental disorders.
机译：海马对于情绪记忆的形成至关重要。在我们的初步研究中，我们发现了海马对情绪刺激的反应与人们的心理稳定性之间的关系。在这项研究中，我们还使用功能磁共振成像（fMRI）评估了情绪刺激将如何影响大脑的杏仁核和丘脑，以及人格稳定性如何与大脑中的反应相关。我们通过Yatabe-Guilford人格测验（Y-G测试）评估了受试者的人格特征，并通过康奈尔医学指数（CMI）评估了心身症状。根据Y-G测验和CMI的总分，将受试者分为精神稳定组和精神不稳定组。使用功能磁共振成像测量情绪刺激下的脑功能反应。进行感兴趣区域（ROI）分析以提取重大变化，以便比较不同情绪刺激之间的反应。我们进行了回归分析，以提取来自功能磁共振成像的平均信号百分比变化与人格稳定性之间的关系。功能磁共振成像结果显示，在人际关系刺激下，海马，丘脑和右杏仁核的活动随着心理不稳定值的增加而增加。我们的发现表明，在与人类有关的刺激下，海马的记忆过程和丘脑的威胁预警系统对精神不稳定者的情绪反应至关重要。大脑中的这些过程会影响对人际关系施加压力的事件，这种关系常常导致人们患有精神疾病。

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