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首页> 外文期刊>Journal of Behavioral and Brain Science >Is There an Association between Temperament and Apolipoprotein E? A Replication of a 1993 Young Finns Study
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Is There an Association between Temperament and Apolipoprotein E? A Replication of a 1993 Young Finns Study

机译：气质与载脂蛋白E之间有关联吗？复制1993年的年轻芬兰人研究

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Background: An association between apolipoprotein E (apoE) gene polymorphism and temperament has been found in the Young Finns cohort. Motor activity in childhood and mental vitality, sociability and positive emotionality in adolescence were associated with apoE. Two research groups have attempted to replicate these findings but no associations have been found. Purpose: The purpose of the present study was to confirm the original findings with new and more reliable genotyping from a larger sample derived from the same Young Finns Study as the original finding.Methods: The study included 2808 participants aged 3 - 18 years in 1980. The same methods in assessing temperament were used as in the original study. Temperament was operationalized as motor activity, cooperativeness, negative emotionality, mental vitality, sociability and positive emotionality. Temperament was assessed by participants’ mothers in 1980 and 1983 and self-rated in 1983 by adolescent participants. Results: Motor activity was not associated with apoE polymerphisms. All other previous results were replicated. Adolescents’ positive emotionality, mental vitality and sociability were associated with apoE. Conclusions: The results indicated that there is an association between temperament and apoE. The previous absence of association between temperament and apoE in the replication studies may be due to the fact that researchers used different dimensions of temperament and thus probably studied different phenomena. Cultural differences in personality assessment might also explain the contradictory findings.
机译：背景：在年轻的芬兰人队列中发现了载脂蛋白E（apoE）基因多态性与气质之间的关联。儿童时期的运动活动和青春期的精神活力，社交能力和积极情绪与apoE相关。两个研究小组试图重复这些发现，但未发现任何关联。目的：本研究的目的是通过来自与原始发现相同的年轻芬兰人研究的较大样本的新的更可靠的基因分型方法来确认原始发现。方法：该研究包括1980年3至18岁的2808名参与者与原始研究中使用的评估气质的方法相同。气质可作为运动活动，合作，消极情绪，精神活力，社交能力和积极情绪来实现。参与者的母亲分别于1980年和1983年对气质进行了评估，并于1983年由青少年参与者进行了自我评估。结果：运动活动与apoE多态性无关。重复了所有其他先前的结果。青少年的积极情绪，精神活力和社交能力与apoE有关。结论：结果表明，气质与apoE之间存在关联。在复制研究中以前没有气质与apoE之间的关联可能是由于以下事实：研究人员使用了不同的气质维度，因此可能研究了不同的现象。人格评估中的文化差异也可能解释了矛盾的发现。

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