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Neopterin in Diagnosis and Monitoring of Infectious Diseases

机译：新蝶呤在传染病的诊断和监测中

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Neopterin is produced by activated monocytes, macrophages, and dendritic cells upon stimulation by interferon gamma produced by T-lymphocytes. Quantification of neopterin in body fluids has been achieved by standard high-performance liquid chromatography, radioimmunoassays, and enzyme-linked immunosorbent assays. Neopterin levels predict HIV-related mortality more efficiently than clinical manifestations. Successful highly active antiretroviral therapy is associated with a decrease in neopterin levels. Elevated neopterin levels were associated with hepatitis by hepatitis A, B, and C viruses. Serum neopterin levels were found to be a predictor of response to treatment of chronic HCV infection with pegylated interferon combined with ribavirin. Neopterin levels of patients with pulmonary tuberculosis were found to be higher in patients with more extensive radiological changes. Elimination of blood donors with elevated neopterin levels to reduce risk of transmission of infections with known and unknown viral pathogens has been undertaken. Neopterin measurement is hereby more cost effective but less sensitive than screening using polymerase chain reaction based assays. In conclusion neopterin is a nonspecific marker of activated T-helper cell 1 dominated immune response. It may be a useful marker for monitoring of infectious disease activity during treatment and for more accurate estimation of extent of disease and prognosis.
机译：新蝶呤是由T淋巴细胞产生的干扰素γ刺激后，由活化的单核细胞，巨噬细胞和树突状细胞产生的。通过标准的高效液相色谱法，放射免疫测定法和酶联免疫吸附测定法已经实现了体液中新蝶呤的定量。新蝶呤水平比临床表现更有效地预测与HIV相关的死亡率。成功的高活性抗逆转录病毒疗法与新蝶呤水平的降低有关。新蝶呤水平升高与甲型，乙型和丙型肝炎病毒引起的肝炎有关。发现血清新蝶呤水平是聚乙二醇化干扰素联合利巴韦林对慢性HCV感染治疗反应的预测指标。影像学变化较广泛的肺结核患者的新蝶呤水平更高。消除了新蝶呤水平升高的献血者，以减少传播已知和未知病毒病原体感染的风险。因此，新蝶呤测量比使用基于聚合酶链反应的测定法筛选更具成本效益，但灵敏度较低。总之，新蝶呤是活化的T辅助细胞1主导的免疫反应的非特异性标记。它对于监测治疗期间的传染病活动以及更准确地估计疾病程度和预后可能是有用的标记。

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