• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Biomarkers >T-Cell Response to Hepatitis B Core Antigen: Identification of Prior Exposure to and Confirmatory Testing for Screening for Anti-HBc
【24h】

T-Cell Response to Hepatitis B Core Antigen: Identification of Prior Exposure to and Confirmatory Testing for Screening for Anti-HBc

机译：T细胞对乙型肝炎核心抗原的反应：事先接触和鉴定性检测抗-HBc的鉴定

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background. During routine donor screening in the blood bank, it is not uncommon to find isolated reactivity for anti-HBc in the absence of detectable HBV DNA in a first donation but absence of reactivity to anti-HBc in subsequent donations, suggesting a false-positive result for anti-HBc. Study Design and Methods. The blood donor population was screened between January 2010 and October 2011. We selected 2,126 donations positive only for anti-HBc from a total of 125,068 donations. During the process, OBI donors were identified, and their HBcAg-specific T-cell response was analyzed and compared to donors with chronic (HBsAg positive) and recovered (anti-HBc only) infection. We analyzed correlations between signal levels (Co/s) in the competitive assay for anti-HBc and HBV DNA detection. Results. In the 21-month study period, 21 blood donors with anti-HBc alone were identified as OBI (1 in each 5955 donors). The relevant finding was the observation that anti-HBc only subjects with did not have either HBcAg-specific T-cells or detectable HBV DNA and OBI subjects presented with and HBcAg T-cell response. In the subset of 21 OBI subjects, 9 donors remained positive for HBcAg T-cell response after four collections. In all 9 samples, we observed HBV DNA fluctuation. Conclusion. Our data suggest that HBcAg-specific T-cell response could be used to confirm anti-HBc serological status, distinguishing previous exposure to Hepatitis B virus from anti-HBc false-positive results.
机译：背景。在血库进行常规献血者筛查期间，在首次献血时没有可检测到的HBV DNA的情况下发现抗HBc的分离反应并不罕见，但在随后的献血中对抗HBc的反应没有发现，提示假阳性结果用于抗HBc。研究设计和方法。在2010年1月至2011年10月之间对献血者人群进行了筛查。我们从125068献血中选择了仅对抗HBc呈阳性的2126献血。在此过程中，确定了OBI供体，并对他们的HBcAg特异性T细胞反应进行了分析，并将其与慢性（HBsAg阳性）和康复（仅抗HBc）感染的供体进行了比较。我们在抗-HBc和HBV DNA检测的竞争性分析中分析了信号水平（Co / s）之间的相关性。结果。在为期21个月的研究期内，有21名仅抗HBc的献血者被确定为OBI（每5955名献血者中有1名）。相关发现是仅抗HBc受试者既没有HBcAg特异性T细胞也没有可检测的HBV DNA和OBI受试者出现HBcAg T细胞反应。在21位OBI受试者的亚组中，经过四次采集后，有9位捐献者的HBcAg T细胞反应仍为阳性。在所有9个样本中，我们观察到HBV DNA波动。结论。我们的数据表明，HBcAg特异性T细胞反应可用于确认抗HBc血清学状况，从而将先前接触过乙型肝炎病毒与抗HBc假阳性结果区分开来。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号