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首页> 外文期刊>Journal of Biomarkers >Day to Day Variability and Reliability of Blood Oxidative Stress Markers within a Four-Week Period in Healthy Young Men
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Day to Day Variability and Reliability of Blood Oxidative Stress Markers within a Four-Week Period in Healthy Young Men

机译：健康年轻人四周内血液氧化应激标志物的每日变化和可靠性

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The present study aimed to determine the day to day variability and reliability of several blood oxidative stress markers at rest in a healthy young cohort over a four-week period. Twelve apparently healthy resistance trained males (24.6 ± 3.0 yrs) were tested over 7 visits within 4 weeks with at least 72 hrs between visits at the same time of day. Subjects rested 30 minutes prior to blood being obtained by vacutainer. Results. The highest IntraClass correlations (ICC’s) were obtained for protein carbonyls (PC) and oxygen radical absorbance capacity (ORAC) (PC = 0.785 and ORAC = 0.780). Cronbach’s α reliability score for PC was 0.967 and for ORAC was 0.961. The ICC’s for GSH, GSSG, and the GSSG/TGH ratio ICC were 0.600, 0.573, and 0.570, respectively, with Cronbach’s α being 0.913, 0.904, and 0.903, respectively. Xanthine oxidase ICC was 0.163 and Cronbach’s α was 0.538. Conclusions. PC and ORAC demonstrated good to excellent reliability while glutathione factors had poor to excellent reliability. Xanthine oxidase showed poor reliability and high variability. These results suggest that the PC and ORAC markers were the most stable and reliable oxidative stress markers in blood and that daily changes across visits should be considered when interpreting resting blood oxidative stress markers.
机译：本研究旨在确定健康的年轻队列在四个星期内在休息时几种血液氧化应激指标的日常变异性和可靠性。在4周内进行了7次就诊，对12名经过健康抵抗力训练的男性进行了测试（24.6±3.0 yrs），在一天中的同一时间两次探访之间至少间隔了72 hr。受试者在抽真空采血之前休息了30分钟。结果。蛋白质羰基（PC）和氧自由基吸收能力（ORAC）的IntraClass相关性（ICC’s）最高（PC = 0.785和ORAC = 0.780）。 Cronbach的PC的α可靠性得分为0.967，而ORAC的α可靠性得分为0.961。 GSH，GSSG和GSSG / TGH比的ICC分别为0.600、0.573和0.570，克朗巴赫（Cronbach's）α分别为0.913、0.904和0.903。黄嘌呤氧化酶的ICC为0.163，克朗巴赫（Cronbach）α为0.538。结论。 PC和ORAC具有良好的可靠性，而谷胱甘肽因子则具有较差的可靠性。黄嘌呤氧化酶显示出较差的可靠性和高可变性。这些结果表明，PC和ORAC标记是血液中最稳定，最可靠的氧化应激标记，在解释静息血液氧化应激标记时，应考虑就诊时的每日变化。

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