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首页> 外文期刊>Journal of Biomarkers >A Panel of Cancer Testis Antigens and Clinical Risk Factors to Predict Metastasis in Colorectal Cancer
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A Panel of Cancer Testis Antigens and Clinical Risk Factors to Predict Metastasis in Colorectal Cancer

机译：一组癌症睾丸抗原和预测大肠癌转移的临床危险因素

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Colorectal cancer (CRC) is the third common carcinoma with a high rate of mortality worldwide and several studies have investigated some molecular and clinicopathological markers for diagnosis and prognosis of its malignant phenotypes. The aim of this study is to evaluate expression frequency of PAGE4, SCP-1, and SPANXA/D cancer testis antigen (CTA) genes as well as some clinical risk markers to predict liver metastasis of colorectal cancer patients. The expression frequency of PAGE4, SCP-1, and SPANXA/D cancer/testis antigen (CTA) genes was obtained using reverse transcription polymerase chain reaction (RT-PCR) assay in 90 colorectal tumor samples including both negative and positive liver metastasis tumors. Statistical analysis was performed to assess the association of three studied genes and clinical risk factors with CRC liver metastasis. The frequency of PAGE4 and SCP-1 genes expression was significantly higher in the primary tumours with liver metastasis when statistically compared with primary tumors with no liver metastasis (). Among all clinical risk factors studied, the lymph node metastasis and the depth of invasion were statistically correlated with liver metastasis of CRC patients. In addition, using multiple logistic regression, we constructed a model based on PAGE4 and lymph node metastasis to predict liver metastasis of CRC.
机译：大肠癌（CRC）是世界范围内死亡率较高的第三种常见癌，一些研究已经研究了一些分子和临床病理学标志物，以诊断和预测其恶性表型。这项研究的目的是评估PAGE4，SCP-1和SPANXA / D癌症睾丸抗原（CTA）基因的表达频率以及一些临床风险标志物，以预测大肠癌患者的肝转移。 PAGE4，SCP-1和SPANXA / D癌症/睾丸抗原（CTA）基因的表达频率是通过逆转录聚合酶链反应（RT-PCR）测定法在90例大肠肿瘤样本中获得的，包括阴性和阳性肝转移肿瘤。进行统计分析以评估三个研究的基因和临床危险因素与CRC肝转移的关联。与无肝转移的原发肿瘤相比，在统计学上与肝转移的原发肿瘤相比，PAGE4和SCP-1基因的表达频率明显更高（）。在所有研究的临床危险因素中，CRC患者的淋巴结转移和浸润深度与肝转移在统计学上相关。此外，使用多元逻辑回归，我们建立了基于PAGE4和淋巴结转移的模型来预测CRC的肝转移。

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