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首页> 外文期刊>Journal of Biomarkers >Biomarkers Predict Relapse in Granulomatosis with Polyangiitis
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Biomarkers Predict Relapse in Granulomatosis with Polyangiitis

机译：生物标志物预测肉芽肿合并多血管炎的复发

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Granulomatosis with polyangiitis (GPA) is a small blood vessel vasculitic disorder with a high mortality rate if undiagnosed or treated inadequately. Disease relapse is a key feature of this disease and early identification of relapse episodes is very important in limiting end-organ damage. The advent of indirect immunofluorescence to detect antineutrophil cytoplasmic antibody (ANCA) with specific reactivity against the enzyme proteinase-3 (PR3) has been very useful in the diagnosis of GPA but is less helpful in predicting relapse. Indeed, up to date no satisfactory biomarker has been identified that can reliably predict relapse. This study assessed the probability of the occurrence of a relapse when a change was noted in a range of commonly used laboratory tests. These tests included levels of C-reactive protein (CRP), anti-PR3 antibodies, ANCA titre, and the neutrophil count. A group of 30 GPA patients with a total of 66 relapse episodes was investigated and a novel clinical yield score was devised. When a combined rise in CRP, anti-PR3 antibodies, and neutrophil count was observed in the 6-month period before a relapse event, 59% of patient relapses could be predicted. Monitoring changes in this set of parameters helps identify disease relapse.
机译：肉芽肿性多血管炎（GPA）是一种小血管血管性疾病，如果不加以诊断或治疗不当，死亡率很高。疾病复发是该疾病的关键特征，早期发现复发发作在限制终末器官损害中非常重要。间接免疫荧光检测对蛋白酶3（PR3）具有特异性反应性的抗中性粒细胞胞浆抗体（ANCA）的出现在诊断GPA方面非常有用，但在预测复发方面却没有多大帮助。实际上，迄今为止，尚未鉴定出能够可靠地预测复发的令人满意的生物标志物。这项研究评估了在一系列常用实验室测试中发现有变化时复发的可能性。这些测试包括C反应蛋白（CRP），抗PR3抗体，ANCA滴度和中性粒细胞计数的水平。研究了一组30位GPA患者，共66次复发发作，并设计了新的临床获益评分。如果在复发事件发生前的6个月内观察到CRP，抗PR3抗体和中性粒细胞计数的综合上升，则可以预测59％的患者复发。监视这组参数的变化有助于识别疾病复发。

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