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首页> 外文期刊>Journal of Biomarkers >Portable XRF Technology to Quantify Pb in Bone In Vivo
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Portable XRF Technology to Quantify Pb in Bone In Vivo

机译：便携式XRF技术可量化体内的铅

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Lead is a ubiquitous toxicant. Bone lead has been established as an important biomarker for cumulative lead exposures and has been correlated with adverse health effects on many systems in the body. K-shell X-ray fluorescence (KXRF) is the standard method for measuring bone lead, but this approach has many difficulties that have limited the widespread use of this exposure assessment method. With recent advancements in X-ray fluorescence (XRF) technology, we have developed a portable system that can quantify lead in bone in vivo within 3 minutes. Our study investigated improvements to the system, four calibration methods, and system validation for in vivo measurements. Our main results show that the detection limit of the system is 2.9 ppm with 2 mm soft tissue thickness, the best calibration method for in vivo measurement is background subtraction, and there is strong correlation between KXRF and portable LXRF bone lead results. Our results indicate that the technology is ready to be used in large human population studies to investigate adverse health effects of lead exposure. The portability of the system and fast measurement time should allow for this technology to greatly advance the research on lead exposure and public/environmental health.
机译：铅是一种普遍存在的有毒物质。骨铅已被确定为累积铅暴露的重要生物标志物，并与对人体许多系统的不良健康影响相关。 K壳X射线荧光（KXRF）是测量骨铅的标准方法，但是该方法存在许多困难，限制了该暴露评估方法的广泛使用。随着X射线荧光（XRF）技术的最新发展，我们开发了一种便携式系统，可以在3分钟内对体内的铅进行定量。我们的研究调查了对系统的改进，四种校准方法以及用于体内测量的系统验证。我们的主要结果表明，该系统的检测极限为2.9 µppm，软组织厚度为2 µmm，体内测量的最佳校准方法是背景扣除，并且KXRF和便携式LXRF骨铅结果之间具有很强的相关性。我们的结果表明，该技术已准备好用于大规模人群研究，以研究铅暴露对健康的不利影响。系统的便携性和快速的测量时间将使这项技术大大促进铅暴露和公共/环境健康的研究。

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