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首页> 外文期刊>Journal of Biomechanical Science and Engineering >A New in Vitro Pulsatile Perfusion System that Mimics Physiological Transmural Pressure and Shear Stress in Any Size of in Vivo Vessel
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A New in Vitro Pulsatile Perfusion System that Mimics Physiological Transmural Pressure and Shear Stress in Any Size of in Vivo Vessel

机译：一种新的体外脉动灌注系统，可模拟任何大小的体内​​血管的生理透壁压力和剪切应力

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References(42) Cited-By(7) The magnitude of pressure and shear stress varies according to anatomical locations and species. It is of the utmost importance that the in vivo condition of these stresses is taken into account in in vitro experiments. In this study, we developed a new in vitro pulsatile perfusion system that is able to mimic pressures and shear stresses with accuracy and over a wide physiological range. Our system is composed of a hydraulic model of a systemic circulation. Pressure and flow rate (i.e., shear stress) were independently controlled by two resistance tubes, and pulse amplitude was controlled by air volume in a compliance tube. The resistance value of two resistance tubes and air volume in a compliance tube were calculated by system simulation. Then we recreated the pressure and shear stress of in vivo measurement data using our system. Results showed mean pressure and mean shear stress at aorta level (100 mmHg and 1.20 Pa), small artery level (80 mmHg and 1.86 Pa), arteriole level (60 mmHg and 1.41 Pa), capillary level (30 mmHg and 0.70 Pa), venule level (20 mmHg and 0.28 Pa), and vena cava level (10 mmHg and 0.15 Pa) to be recreated. We also exposed cultured human aortic endothelial cells (HAEC) to physiological pulsatile flow, which was similar to that in the human aorta at pressure 80/120 mmHg and shear stress 1.0/1.5 Pa. In the results, HAEC was elongated and oriented in the flow direction.
机译：参考文献（42）引用依据（7）压力和剪切应力的大小根据解剖位置和种类而变化。最重要的是在体外实验中要考虑这些应激的体内条件。在这项研究中，我们开发了一种新的体外脉动灌注系统，该系统能够在广泛的生理范围内准确模拟压力和切应力。我们的系统由系统循环的水力模型组成。压力和流速（即剪切应力）由两个电阻管独立控制，脉冲幅度由柔量管中的空气量控制。通过系统仿真计算出两个电阻管的电阻值和顺应性管中的空气量。然后，我们使用我们的系统重新创建了体内测量数据的压力和切应力。结果显示主动脉水平（100 mmHg和1.20 Pa），小动脉水平（80 mmHg和1.86 Pa），小动脉水平（60 mmHg和1.41 Pa），毛细管水平（30 mmHg和0.70 Pa）的平均压力和平均剪切应力，静脉水平（20 mmHg和0.28 Pa）和腔静脉水平（10 mmHg和0.15 Pa）将重新创建。我们还将培养的人主动脉内皮细胞（HAEC）暴露于生理脉动流，这与人主动脉在压力80/120 mmHg和剪切应力1.0 / 1.5 Pa下的脉动流相似。结果，HAEC在血管中伸长并定向。流动的方向。

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