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首页> 外文期刊>Journal of Advances in Medical and Pharmaceutical Sciences >Comparative Study on Efficacy of Intrathecal Injection Midazolam (2 mg) Versus Injection Metoclopramide IV in Prevention or Reduction of Nausea and Vomiting in Women during Caesarean Delivery under Spinal Anaesthesia
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Comparative Study on Efficacy of Intrathecal Injection Midazolam (2 mg) Versus Injection Metoclopramide IV in Prevention or Reduction of Nausea and Vomiting in Women during Caesarean Delivery under Spinal Anaesthesia

机译：鞘内注射咪达唑仑（2 mg）与注射甲氧氯普胺IV预防或减少剖宫产术中妇女在脊髓麻醉下恶心和呕吐的疗效比较研究

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Background: Nausea and vomiting after spinal anaesthesia in caesarean are frequent causing distress to the patient and surgeon. To diminish the incidence various pharmacological agents were used with their limitations. This study compares intrathecal midazolam with intravenous metoclopramide for prevention of nausea and vomiting during surgery and in the early postoperative period after caesarean delivery performed with spinal anaesthesia. Materials and Methods: In a randomized single blind manner, 100 women (ASA Grade I and II) undergoing elective caesarean delivery were enrolled for the study with 0.5% hyperbaric bupivacaine 2 ml (10 mg) spinal anaesthesia were randomly allocated in to two groups. Group I received intravenous metoclopramide 10 mg (n = 50 in each group). Group II received intrathecal midazolam preservative free 2 mg (n = 50). Emetic episodes were recorded during anaesthesia and in the initial period after caesarean delivery (0 – 6 hrs) and compared between two groups by using Chi – square test. P value of <0.05 was taken to be significant. Results: The incidence of patients who were emesis – free in the intraoperative and postoperative period was 39 (78%) with intravenous metoclopramide and 49 (98%) with intrathecal midazolam, respectively (p< 0.001). No clinically important adverse events were observed in either group. Conclusion: We conclude that use of intrathecal midazolam (2 mg) is more effective than intravenous metoclopramide (10 mg) for preventing nausea and vomiting in women undergoing caesarean delivery under spinal anaesthesia with bupivacaine (0.5%) hyperbaric.
机译：背景：剖宫产术中脊髓麻醉后的恶心和呕吐经常给患者和外科医生带来困扰。为了减少发病率，使用了各种局限性的药物。这项研究比较了鞘内注射咪达唑仑和静脉注射甲氧氯普胺在预防术中以及在进行剖腹产并进行麻醉后的术后早期恶心和呕吐的情况。材料和方法：以随机单盲方式，将100名接受择期剖腹产的妇女（ASA I和II级）纳入研究，将0.5％的高压布比卡因2 ml（10 mg）脊柱麻醉随机分为两组。第一组接受静脉注射甲氧氯普胺10 mg（每组n = 50）。第二组接受鞘内注射咪达唑仑防腐剂2 mg（n = 50）。在麻醉期间和剖腹产后的最初阶段（0 – 6小时）记录催吐次数，并通过卡方检验比较两组之间的呕吐情况。 ＜0.05的P值被认为是显着的。结果：术中和术后无呕吐的患者术中静脉注射甲氧氯普胺的发生率为39（78％），鞘内注射咪达唑仑的为49（98％）（p <0.001）。两组均未观察到临床上重要的不良事件。结论：我们得出的结论是，鞘内注射咪达唑仑（2 mg）比静脉注射甲氧氯普胺（10 mg）对在使用布比卡因（0.5％）高压麻醉下进行剖腹产剖腹产的妇女预防恶心和呕吐更为有效。

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