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首页> 外文期刊>Journal of Advances in Medical and Pharmaceutical Sciences >Acute and Sub-acute Toxicity of HRT 123 Polyherbal Formula
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Acute and Sub-acute Toxicity of HRT 123 Polyherbal Formula

机译：HRT 123多草药配方的急性和亚急性毒性

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Plant based drugs (single or multi-component formulations) have been used in managing many health conditions worldwide. One such formulation is the herbal formula HRT 123 which is being used in managing conditions involving immunosuppression, HIV/AIDs and other infectious diseases of viral origin. This study screened for phytochemical constituents and evaluates acute and sub acute toxicity profile of aqueous HRT 123 extract. We evaluated acute toxicity of HRT 12 aqueous extract using the modified Arithmetic method of Karbar and sub-acute toxicity using the 14-day repeated dose oral toxicity testing procedure. For sub acute toxicity, thirty albino rats divided into five groups of six rats each received 0, 250, 500, 750, and 1000 mg/kg of extract respectively by oral route for 14 days. Animals were sacrificed and blood analyzed for haematological parameters, serum biomarkers and electrolytes while visceral organs (lungs, heart, liver, kidneys & spleen) were harvested for histopathological investigations. Phytochemical screening shows presence of alkaloids, saponins, tannins, flavonoids and carbohydrates. Acute toxicity shows oral LD50 to be more than 6000 mg/kg. Following sub acute administration, indices of liver (AST, ALT, total protein & albumin) and renal (sodium, potassium, chloride & creatinine) function and; haematological parameters were not significantly different in treated groups relative to controls. Liver weight displayed a dose dependent increase while the kidneys showed relative but non-significant decrease. These results are suggestive of the relative safety of HRT 123 but caution needs to be exercised with used of high doses and in the face of concomitant liver or kidney abnormality.
机译：植物性药物（单或多组分制剂）已用于管理全球许多健康状况。一种这样的制剂是草药制剂HRT 123，其用于处理涉及免疫抑制，HIV / AID和其他病毒源性传染病的疾病。这项研究筛选了植物化学成分，并评估了HRT 123水溶液提取物的急性和亚急性毒性。我们使用改良的Karbar算术方法评估了HRT 12水提取物的急性毒性，并使用14天重复剂量口服毒性测试程序评估了亚急性毒性。对于亚急性毒性，将三十只白化病大鼠分为五组，每组六只，分别通过口服途径分别接受0、250、500、750和1000 mg / kg的提取物14天。处死动物并分析血液的血液学参数，血清生物标志物和电解质，同时收集内脏器官（肺，心脏，肝脏，肾脏和脾脏）进行组织病理学研究。植物化学筛选显示存在生物碱，皂苷，单宁，类黄酮和碳水化合物。急性毒性显示口服LD 50 大于6000 mg / kg。亚急性给药后，肝（AST，ALT，总蛋白和白蛋白）和肾（钠，钾，氯和肌酐）的功能指标以及相对于对照组，治疗组的血液学参数没有显着差异。肝重量显示剂量依赖性增加，而肾脏显示相对但不显着降低。这些结果暗示了HRT 123的相对安全性，但在高剂量使用以及面对肝脏或肾脏异常的情况下，应谨慎行事。

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