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首页> 外文期刊>Journal of Advances in Internal Medicine >Systemic Lupus Erythematosus presenting with Bullous lesion, Lupus Nephritis and Seizure
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Systemic Lupus Erythematosus presenting with Bullous lesion, Lupus Nephritis and Seizure

机译：系统性红斑狼疮伴大疱性病变，狼疮性肾炎和癫痫发作

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Development of bullous lesion is a rare cutaneous manifestation of systemic lupus erythematosus (SLE). Bullous eruptions in SLE are divided into three categories. Firstly, the lesions of SLE may blister. Secondly, a number of primarily blistering diseases have been associated with SLE.Thirdly, bullous SLE (BSLE), characterized bysub-epidermal blisters, IgG deposition at the dermoepidermal junction and autoantibodies against collagen VII, forms a distinct group. We report an18 years girl who met American College of Rheumatology diagnostic criteria for SLE presenting with bullous lesion and nephritis and developed seizure during the same admission. She had anti-nuclear antibody positive, anti-DsDNA antibody negative and serum complement, C3, level decreased. She was managed with steroid, hydroxychloroquine and cyclophosphamide to which her renal function improved significantly and the skin lesions remitted partially. We would also like to highlight the difficulties in establishing differential diagnoses of bullous lesion in SLE. Journal of Advances in Internal Medicine 2013;02(01):17-20 DOI: http://dx.doi.org/10.3126/jaim.v2i1.7633
机译：大疱性病变的发展是系统性红斑狼疮（SLE）的罕见皮肤表现。 SLE中的大疱性爆发分为三类。首先，SLE的病变可能会起泡。其次，许多主要的水疱性疾病与SLE有关。第三，大疱性SLE（BSLE）以表皮下水泡，真皮表皮交界处的IgG沉积以及针对胶原蛋白VII的自身抗体为特征。我们报告了一位18岁女孩，该女孩符合美国风湿病学院对SLE的诊断标准，并伴有大疱性病变和肾炎，并在同一次入院时出现癫痫发作。她的抗核抗体阳性，抗DsDNA抗体阴性，血清补体C3水平降低。她接受了类固醇，羟氯喹和环磷酰胺的治疗，肾功能显着改善，皮肤病变部分缓解。我们还要强调在建立SLE大疱性病变的鉴别诊断方面的困难。内科学进展杂志2013; 02（01）：17-20 DOI：http://dx.doi.org/10.3126/jaim.v2i1.7633

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