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首页> 外文期刊>Journal of Advances in Medical and Pharmaceutical Sciences >Biochemical Assessment of Parkia biglobosa Ethanolic Root Extract in Streptozotocin Induced Diabetic Rats
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Biochemical Assessment of Parkia biglobosa Ethanolic Root Extract in Streptozotocin Induced Diabetic Rats

机译：链脲佐菌素致糖尿病大鼠大叶柏木乙醇根提取物的生化评估

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Aim: To investigate the antidiabetic effect of Parkia biglobosa ethanolic root extract in streptozotocin induced diabetic rats. Place and Duration of Study: Department of Biochemistry, College of Natural Sciences, Joseph Ayo Babalola University, Ikeji Arakeji Osun State, Nigeria, between October 2014 and August, 2015. Methodology: Sixty adult female Wistar rats weighing between 120-190 g were divided into six study groups I, II, III, IV, V, VI, (n=8) weighing between 120-190 g. Group 1 was designated as positive control and received distilled water, group II was designated as negative control and received (1 ml) of streptozotocin, group III was designated as diabetes induced and orthodox and received (1 ml) of Insulin, groups IV, V and VI were designated as diabetes induced and extract treated groups and received (250 mg/dl, 500 mg/dl and 1000 mg/dl) respectively. Results: The phytochemical screening of the ethanolic root extract showed the presence of flavonoids, tannin, saponins, cardiac glycosides, phenolics, terpenoid and oxalate. There was a significant decrease in blood glucose levels of diabetes treated groups VI, V and VI at the end of the experiment which portrays the therapeutic efficacy of Parkia biglobosa ethanolic root extract in ameliorating diabetic condition. There was a significant decrease in Alanine transaminases (ALT), Aspartate transaminase (AST) and Alkaline phosphotase in extract treated groups compared with negative control. However, Total cholesterol, High density lipoprotein (HDL), and Triglycerides (TG) shown increase which was not significant compared to the negative control but Low density lipoprotein (LDL) depicted decrease which was significant compared with the negative control. Conclusion: The results obtained from all these assays justify the therapeutic efficacy of Parkia biglobosa root extract to ameliorate diabetic condition.
机译：目的：探讨Parkia biglobosa乙醇根提取物对链脲佐菌素诱导的糖尿病大鼠的抗糖尿病作用。研究的地点和时间：2014年10月至2015年8月，尼日利亚约克艾克西·阿拉克吉·奥孙州约瑟夫·阿约·巴巴拉拉大学自然科学学院生物化学系。方法：将60只成年雌性Wistar大鼠分为120-190 g分为六个研究组I，II，III，IV，V，VI（n = 8），重量在120-190 g之间。第一组被指定为阳性对照并接受蒸馏水，第二组被指定为阴性对照并接受（1 ml）链脲佐菌素，第三组被指定为糖尿病引起的和正统的，并接受（1 ml）胰岛素，IV，V组将分别以250mg / dl，500mg / dl和1000mg / dl的剂量给予糖尿病和VI诱导的糖尿病和提取物治疗组。结果：乙醇根提取物的植物化学筛选显示出黄酮，单宁，皂角苷，强心苷，酚类，萜类和草酸的存在。在实验结束时，糖尿病治疗的VI，V和VI组的血糖水平显着降低，反映了Parkia biglobosa乙醇根提取物在改善糖尿病状态下的治疗效果。与阴性对照组相比，提取物处理组的丙氨酸转氨酶（ALT），天冬氨酸转氨酶（AST）和碱性磷酸酶显着降低。但是，总胆固醇，高密度脂蛋白（HDL）和甘油三酸酯（TG）显示增加，与阴性对照相比，这并不显着，但是低密度脂蛋白（LDL）却显示与阴性对照相比是显着的。结论：从所有这些测定中获得的结果证明了大叶柏根提取物改善糖尿病状况的治疗功效。

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