...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cachexia, Sarcopenia and Muscle >A pilot study of temsirolimus and body composition
【24h】

A pilot study of temsirolimus and body composition

机译：替西罗莫司和身体成分的初步研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PurposeBody weight and composition play a role in cancer etiology, prognosis, and treatment response. Therefore, we analyzed the weight, body composition changes, and outcome in patients treated with temsirolimus, an mTor inhibitor that has weight loss as one of its side effects.Patients and methodsSixteen patients with advanced solid tumors treated with temsirolimus were studied; body composition was evaluated utilizing computerized tomography images. Sarcopenia was defined as skeletal muscle index lower than 38.5?cm2/m2 for women and 52.4?cm2/m2 for men.ResultsFive of 16 patients (31?%) were men; median age, 60?years. Forty-four percent (7/16) of patients were sarcopenic. Fatigue, anemia, hyperglycemia, and hyperlipidemia were common. Baseline sarcopenia and body composition did not correlate with worse toxicity or treatment outcome. However, there was a trend for greater loss of adipose area (p?=?0.07), fat mass (p?=?0.09), and adipose index (p?=?0.07) for patients with grade 3 or 4 toxicities versus those with grade 1 and 2 side effects.ConclusionPatients with higher grade toxicities tended to lose more body fat, suggesting a possible end-organ metabolic effect of temsirolimus. These observations merit exploration in a larger cohort of patients.
机译：目的体重和组成在癌症病因，预后和治疗反应中起作用。因此，我们分析了以temsirolimus（一种以体重减轻为副作用之一）的mTor抑制剂治疗的患者的体重，身体组成变化和结局。患者和方法研究了16例接受temsirolimus治疗的晚期实体瘤患者。利用计算机断层扫描图像评估身体成分。肌肉减少症的定义是女性的骨骼肌指数低于38.5？cm2 / m2，男性的骨骼肌指数低于52.4？cm2 / m2。结果16例患者中有5例（31％）是男性;中位年龄为60岁。 44％（7/16）的患者患有肌肉减少症。疲劳，贫血，高血糖和高脂血症很常见。基线肌肉减少症和身体组成与不良毒性或治疗结果无关。但是，与3种或4种毒性反应相比，有3种或4种毒性反应的患者有更大的脂肪流失面积（p≤0.07），脂肪量（p≤0.09）和脂肪指数（p≤0.07）。结论：具有较高等级毒性的患者往往会损失更多的体内脂肪，提示西罗莫司可能具有终末器官代谢作用。这些观察结果值得在更大范围的患者中进行探索。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号