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首页> 外文期刊>Journal of Cachexia, Sarcopenia and Muscle >Exercise for cancer cachexia in adults: Executive summary of a Cochrane Collaboration systematic review
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Exercise for cancer cachexia in adults: Executive summary of a Cochrane Collaboration systematic review

机译：成人癌症恶病质的锻炼：Cochrane Collaboration系统评价的执行摘要

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AbstractBackgroundCancer cachexia is a complex syndrome characterized by an ongoing loss of skeletal muscle mass and progressive functional impairment. A proactive management approach is recommended, including physical exercise to maintain function via modulation of muscle metabolism, insulin sensitivity and levels of inflammation. The review aimed to determine the safety, acceptability and effectiveness of exercise in adults with cancer cachexia. Secondary aims, subject to the data availability, were to compare effectiveness according to the characteristics of the study intervention or population.MethodsWe sought randomised controlled trials (RCTs) in adults meeting international criteria for cancer cachexia, comparing a programme of exercise as a sole or adjunct intervention to usual care or an active control. CENTRAL, MEDLINE, EMBASE, DARE and HTA, ISI Web of Science, LILACS, PEDro, SciVerse SCOPUS, Biosis Previews PreMEDLINE and Open Grey databases were searched up to June 2014. Two authors independently assessed studies for eligibility.ResultsWe screened 3154 separate titles and abstracts, and reviewed 16 full-texts. Corresponding authors were contacted to determine if samples met cachexia staging criteria. Most authors did not explore this concept. No trial met review eligibility criteria. We were unable to perform a meta-analysis to determine any effects from exercise intervention.ConclusionDespite a strong rationale for the use of exercise, there is insufficient evidence to determine safety and effectiveness in patients with cancer cachexia. Findings from ongoing studies are awaited. Assessment of cachexia domains, ideally against international criteria, is required for future trials of exercise and supportive care interventions.
机译：摘要背景癌症恶病质是一种复杂的综合征，其特征是骨骼肌质量持续下降和进行性功能障碍。建议采取积极的管理方法，包括进行体育锻炼以通过调节肌肉代谢，胰岛素敏感性和炎症水平来维持功能。这项审查旨在确定癌症恶病质成人锻炼的安全性，可接受性和有效性。次要目标是根据数据的可获得性，根据研究干预措施或人群的特征比较有效性。方法我们寻求在符合国际标准的癌症恶病质的成年人中进行随机对照试验（RCT），将一项运动计划作为一项单独或比较对常规护理或积极控制的辅助干预。截至2014年6月，检索了CENTRAL，MEDLINE，EMBASE，DARE和HTA，ISI Web of Science，LILACS，PEDro，SciVerse SCOPUS，Biosis Previews PreMEDLINE和Open Gray数据库。两名作者独立评估了研究的资格。结果我们筛选了3154个单独的标题和摘要，并审查了16篇全文。与通讯作者联系以确定样品是否符合恶病质分期标准。大多数作者没有探索这个概念。没有试验符合审查资格标准。我们无法进行荟萃分析来确定运动干预的任何效果。结论尽管有充分的理由使用运动，但尚无足够的证据确定癌症恶病质患者的安全性和有效性。等待进行中的研究结果。理想情况下，应根据国际标准对恶病质域进行评估，以进行运动和支持治疗干预措施的未来试验。

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