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首页> 外文期刊>Journal of Cachexia, Sarcopenia and Muscle >Diet composition as a source of variation in experimental animal models of cancer cachexia
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Diet composition as a source of variation in experimental animal models of cancer cachexia

机译：饮食组成是癌症恶病质实验动物模型变异的来源

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Abstract Background A variety of experimental animal models are used extensively to study mechanisms underlying cancer cachexia, and to identify potential treatments. The important potential confounding effect of dietary composition and intake used in many preclinical studies of cancer cachexia is frequently overlooked. Dietary designs applied in experimental studies should maximize the applicability to human cancer cachexia, meeting the essential requirements of the species used in the study, matched between treatment and control groups as well as also being generally similar to human consumption. Methods A literature review of scientific studies using animal models of cancer and cancer cachexia with dietary interventions was performed. Studies that investigated interventions using lipid sources were selected as the focus of discussion. Results The search revealed a number of nutrient intervention studies (n = 44), with the majority including n-3 fatty acids (n = 16), mainly eicosapentaenoic acid and/or docosahexaenoic acid. A review of the literature revealed that the majority of studies do not provide information about dietary design; food intake or pair-feeding is rarely reported. Further, there is a lack of standardization in dietary design, content, source, and overall composition in animal models of cancer cachexia. A model is proposed with the intent of guiding dietary design in preclinical studies to enable comparisons of dietary treatments within the same study, translation across different study designs, as well as application to human nutrient intakes. Conclusion The potential for experimental endpoints to be affected by variations in food intake, macronutrient content, and diet composition is likely. Diet content and composition should be reported, and food intake assessed. Minimum standards for diet definition in cachexia studies would improve reproducibility of pre-clinical studies and aid the interpretation and translation of results to humans with cancer.
机译：摘要背景各种各样的实验动物模型被广泛用于研究癌症恶病质的潜在机制，并确定潜在的治疗方法。在许多癌症恶病质的临床前研究中，饮食成分和摄入量的重要潜在混杂效应经常被忽视。实验研究中使用的饮食设计应最大限度地提高对人类癌症恶病质的适用性，满足研究中所用物种的基本要求，在治疗组和对照组之间进行匹配，并且通常与人类食用相似。方法：采用饮食干预措施对癌症和恶病质恶病的动物模型进行科学研究的文献综述。选择使用脂质来源调查干预措施的研究作为讨论的重点。结果搜索显示了许多营养干预研究（n = 44），大多数包括n-3脂肪酸（n = 16），主要是二十碳五烯酸和/或二十二碳六烯酸。对文献的回顾表明，大多数研究未提供有关饮食设计的信息。很少有食物摄入或配对喂养的报道。此外，在癌症恶病质的动物模型中，饮食设计，含量，来源和总体组成方面缺乏标准化。提出了一种旨在指导临床前研究中饮食设计的模型，以比较同一研究中的饮食疗法，翻译不同研究设计以及应用于人类营养摄入。结论实验终点可能受到食物摄入量，大量营养素含量和饮食组成变化的影响。应报告饮食含量和成分，并评估食物摄入量。恶病质研究中饮食定义的最低标准将提高临床前研究的可重复性，并有助于将结果解释和翻译给患有癌症的人。

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