• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cachexia, Sarcopenia and Muscle >Sarcopenia and mortality among a population-based sample of community-dwelling older adults
【24h】

Sarcopenia and mortality among a population-based sample of community-dwelling older adults

机译：人群中老年人居住的人群中的肌肉减少症和死亡率

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Background Sarcopenia is a risk-factor for all-cause mortality among older adults, but it is unknown if sarcopenia predisposes older adults to specific causes of death. Further, it is unknown if the prognostic role of sarcopenia differs between males and females, and obese and non-obese individuals. Methods A population-based cohort study among 4425 older adults from the Third National Health and Nutrition Survey (1988?￠????1994). Muscle mass was quantified using bioimpedance analysis, and muscle function was quantified using gait speed. Multivariable-adjusted Cox regression analysis examined the relationship between sarcopenia and mortality outcomes. Results The mean age of study participants was 70.1 years. The prevalence of sarcopenia was 36.5%. Sarcopenia associated with an increased risk of all-cause mortality [hazard ratio (HR): 1.29 (95% confidence interval (95% CI): 1.13?￠????1.47); P < 0.001] among males and females. Sarcopenia associated with an increased risk of cardiovascular-specific mortality among females [HR: 1.61 (95% CI: 1.22?￠????2.12); P = 0.001], but not among males [HR: 1.07 (95% CI: 0.81?￠????1.40; P = .643); P interaction = 0.079]. Sarcopenia was not associated with cancer-specific mortality among males and females [HR: 1.07 (95% CI: 0.78?￠????1.89); P = 0.672]. Sarcopenia associated with an increased risk of mortality from other causes (i.e. non-cardiovascular and non-cancer) among males and females [HR: 1.32 (95% CI: 1.07?￠????1.62); P = 0.008]. Obesity, defined using body mass index ( P interaction = 0.817) or waist circumference ( P interaction = 0.219) did not modify the relationship between sarcopenia and all-cause mortality. Conclusions Sarcopenia is a prevalent syndrome that is associated with premature mortality among community-dwelling older adults. The prognostic value of sarcopenia may vary by cause-specific mortality and differ between males and females.
机译：摘要背景肌肉减少症是老年人全因死亡的危险因素，但肌肉减少症是否会使老年人倾向于特定的死亡原因尚不清楚。此外，男性和女性，肥胖者和非肥胖者之间的少肌症的预后作用是否不同尚不清楚。方法根据第三次全国健康与营养调查（1988年至1994年）在4425名老年人中进行的基于人群的队列研究。使用生物阻抗分析定量肌肉质量，使用步态速度定量肌肉功能。多变量调整的Cox回归分析检查了肌肉减少症与死亡率结果之间的关系。结果研究参与者的平均年龄为70.1岁。肌肉减少症的患病率为36.5％。肌肉减少症与全因死亡风险增加相关[危险比（HR）：1.29（95％置信区间（95％CI）：1.13）1.47。男性和女性之间P <0.001]。肌肉减少症与女性心血管特异性死亡风险增加有关[HR：1.61（95％CI：1.22→2.12）; P = 0.001]，但男性并非如此[HR：1.07（95％CI：0.81≤1.40; P = .643）; P相互作用= 0.079]。肌肉减少症与男性和女性的癌症特异性死亡率无关[HR：1.07（95％CI：0.78→1.89）; P = 0.672]。肌肉减少症与男性和女性因其他原因（即非心血管疾病和非癌症）致死风险增加有关[HR：1.32（95％CI：1.07≤1.62）; P = 0.008]。用体重指数（P相互作用= 0.817）或腰围（P相互作用= 0.219）定义的肥胖症并没有改变肌肉减少症与全因死亡率之间的关系。结论肌肉减少症是一种普遍的综合征，与社区居住的老年人过早死亡有关。肌肉减少症的预后价值可能因特定原因的死亡率而异，并且男性和女性之间也有所不同。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号