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首页> 外文期刊>Journal of Biomedical Science and Engineering >Polymer-based nanoparticulate solid dispersions prepared by a modified electrospraying process
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Polymer-based nanoparticulate solid dispersions prepared by a modified electrospraying process

机译：通过改进的电喷雾工艺制备的聚合物基纳米颗粒固体分散体

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A modified electrospraying process is exploited to enhance the dissolution profiles of a poorly water-soluble drug. With polyvinylpyrrolidone (PVP) as a hydrophilic polymer matrix and ketoprofen (KET) as a model drug, polymer-drug composites in the form of nanoparticles were prepared and characterized. The surface morphologies, the physical status of the drug, and the drug-polymer interactions were studied using FESEM, DSC, XRD, and ATR-FTIR. FESEM observations demonstrated that the nanoparticles gradually decreased in size from 640 ± 350, to 530 ± 320, 460 ± 200 and 320 ± 160 nm as the KET content increased from 0, to 9.1%, 16.7% and 33.3% w/w, respectively. Results from DSC and XRD suggested that KET was distributed in the PVP matrix in an amorphous manner at the molecular level. This is thought to be due to their compatibility, arising through hydrogen bonding as demonstrated by ATR- FTIR spectra. In vitro dissolution tests showed that the nanoparticles released the incorporated KET within 1 min, evidencing markedly improved dissolution over pure KET and a KET-PVP physical mixture. Electrospraying can hence offer a facile route to develop new polymer composites for biomedical applications, in particular for improving dissolution rate of poorly water-soluble drugs.
机译：开发了一种改进的电喷雾工艺来增强水溶性差的药物的溶出度。以聚乙烯吡咯烷酮（PVP）为亲水性聚合物基质，酮洛芬（KET）为模型药物，制备并表征了纳米颗粒形式的聚合物-药物复合物。使用FESEM，DSC，XRD和ATR-FTIR研究了药物的表面形态，药物的物理状态以及药物与聚合物的相互作用。 FESEM观察表明，随着KET含量从0增加到9.1 ％，16.7 ％和33.3 ％w /，纳米粒子的尺寸从640±350逐渐减小到530±320、460±200和320±160 nm。 w，分别。 DSC和XRD的结果表明，KET在分子水平上以无定形方式分布在PVP基质中。据认为，这是由于它们的相容性，如ATR-FTIR光谱所示，是通过氢键形成的。体外溶出度测试表明，纳米粒子在1分钟内释放了掺入的KET，这表明与纯KET和KET-PVP物理混合物相比，溶出度显着提高。因此，电喷雾可以提供一种简便的途径来开发用于生物医学应用的新的聚合物复合材料，特别是用于提高水溶性差的药物的溶解速率。

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