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首页> 外文期刊>Journal of Biomedical Science and Engineering >Investigation of changes in thickness and reflectivity from layered retinal structures of healthy and diabetic eyes with optical coherence tomography
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Investigation of changes in thickness and reflectivity from layered retinal structures of healthy and diabetic eyes with optical coherence tomography

机译：用光学相干断层扫描技术研究健康和糖尿病眼的分层视网膜结构的厚度和反射率的变化

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OCT is usually employed for the measurement of retinal thickness. However, coherent reflected light carries more information characterizing the optical properties of tissue. Therefore, optical property changes may provide further information regarding cellular layers and early damage in ocular diseases. We investigated the possibility of OCT in detecting changes in the optical backscattered signal from layered retinal structures. OCT images were obtained from diabetic patients without retinopathy (DM, n = 38 eyes) or mild diabetic retinopathy (MDR, n = 43 eyes) and normal healthy subjects (n = 74 eyes). The thickness and reflectivity of various layered structures were assessed using a custom-built algorithm. In addition, we evaluated the usefulness of quantifying the reflectivity of layered structures in the detection of retinal damage. Generalized estimating equations considering within-subject inter-eye relations were used to test for differences between the groups. A modified p value of <0.001 was considered statistically significant. Receiver operating characteristic (ROC) curves were constructed to describe the ability of each parameter to discriminate between the eyes of DM, MDR and healthy eyes. Thickness values of the GCL + IPL and OPL showed a significant decrease in the MDR eyes compared to controls. Significant decreases of total reflectance average values were observed in all layers in the MDR eyes compared with controls. The highest AUROC values estimated for the total reflectance were observed for the GCL+IPL, OPL and OS when comparing MDR eyes with controls. Total reflectance showed a better discriminating power between the MDR eyes and healthy eyes compared to thickness values. Our results suggest that the optical properties of the intraretinal layers may provide useful information to differentiate pathological from healthy eyes. Further research is warranted to determine how this approach may be used to improve diagnosis of early retinal neurodegeneration.
机译：OCT通常用于测量视网膜厚度。但是，相干反射光会携带更多表征组织光学特性的信息。因此，光学性质的变化可提供有关细胞层和眼部疾病早期损伤的更多信息。我们研究了OCT在检测来自分层视网膜结构的光学反向散射信号中的变化的可能性。从没有视网膜病变（DM，n = 38眼）或轻度糖尿病视网膜病变（MDR，n = 43眼）和正常健康受试者（n = 74眼）的糖尿病患者获得OCT图像。使用定制算法评估各种分层结构的厚度和反射率。此外，我们评估了量化分层结构的反射率在检测视网膜损伤中的有用性。考虑对象间眼内关系的广义估计方程用于测试组之间的差异。修正的p值<0.001被认为具有统计学意义。构造接收器工作特性（ROC）曲线来描述每个参数区分DM，MDR和健康眼睛的能力。与对照相比，GDR + IPL和OPL的厚度值显示MDR眼睛显着减少。与对照相比，在MDR眼睛的所有层中均观察到总反射率平均值的显着下降。当比较MDR眼睛和对照组时，观察到了GCL + IPL，OPL和OS的最高总反射率AUROC值。与厚度值相比，总反射率显示MDR眼睛和健康眼睛之间更好的辨别力。我们的结果表明，视网膜内层的光学性质可能提供有用的信息，以区分病理学与健康的眼睛。有必要进行进一步的研究以确定这种方法如何用于改善早期视网膜神经变性的诊断。

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