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首页> 外文期刊>Journal of Biomedical Science and Engineering >Molecular adsorbent recirculating system therapy in a rare case of fulminant hepatitis
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Molecular adsorbent recirculating system therapy in a rare case of fulminant hepatitis

机译：罕见的暴发性肝炎病例的分子吸附剂再循环系统治疗

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Background: Acute hepatitis C virus infection leading to fulminant hepatitis is very rare whereas Hepatitis C virus (HCV) infection is one of the main causes of chronic liver disease worldwide. The repertoire of substances that accumulate in the blood in fulminant hepatic failure cause neurological abnormalities, aggravate injury to the liver and other organs, suppress the ability of residual hepatocytes to perform organ-specific functions (sick cell syndrome), and inhibit the hepatic regenerative response especially in fulminant hepatitis Virus C which has subacute clinical evolution and takes time to manifest. Liver support technology is evolving as different techniques become available that assist the remaining functional cell mass by providing specific liver functions. Case Presentation: We report a case of Fulminant C virus Hepatitis, successfully treated with albumin dialysis Molecular Adsorbent Recirculating System (MARS). At time of admittance the patient presented: Model End-stage Liver Disease (MELD)-36; Child Turcotte Pugh (CTP)-C(13); Sequential Organ Failure Assestment (SOFA)-12, Glasgow Coma Score (GCS)-11. The patient underwent six sessions of MARS in Intensive Care Unit (ICU) in association with standard medical therapy (SMT). The patient survived and was discharged from the hospital in good condition after 40 days without liver transplantation (LT).
机译：背景：导致暴发性肝炎的急性丙型肝炎病毒感染非常罕见，而丙型肝炎病毒（HCV）感染是全世界慢性肝病的主要原因之一。暴发性肝衰竭时血液中积聚的物质种类会导致神经系统异常，加重对肝脏和其他器官的伤害，抑制残留肝细胞执行器官特定功能（病细胞综合征）的能力，并抑制肝再生反应特别是在暴发性丙型肝炎病毒C中，该病毒的临床发展较慢，并且需要时间才能显现出来。肝支持技术正在发展，因为可利用不同的技术通过提供特定的肝功能来辅助剩余的功能细胞团。病例介绍：我们报告了一例C型肝炎病毒，成功用白蛋白透析分子吸附剂再循环系统（MARS）治疗。入院时患者表现为：晚期肝病模型（MELD）-36;儿童Turcotte Pugh（CTP）-C（13）;器官功能衰竭评估（SOFA）-12，格拉斯哥昏迷评分（GCS）-11。该患者与标准药物治疗（SMT）一起在重症监护病房（ICU）接受了六个疗程的MARS。患者存活40天，未进行肝移植（LT），但存活下来并康复出院。

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